Effects Of Dexmedetomidine On Blood Glucose And Hemodynamics In The Elderly Patients With Type 2 Diabetes And Colorectal Cancer Under General Anesthesia

ObjectiveTo observe the effects of dexmedetomidine on blood glucose and hemodynamics in the elderly patients with type2 diabetes under general anesthesia and colorectal cancer surgery,to explore if dexmede-tomidine can reduce degree of stress reaction.MethodsForty-eight elderly patients with type 2 diabetes undergoing colorectal cancer surgery were randomly divided into two groups:dexmedetomidine group（group A）,control group（group B）,24cases in each group.Group A received midazolam,cisatrac-urium besilate,sufentany,etomidate,ruifentany,diprivan and dexmedetomidine:Group B receiveed midazolam,cisatracurium,besilate,sufentany,etomidate,ruifentany,diprivan without dexmed-etomidine.The vital signs（BP,HR）were recorded.Blood samples were recorded before anesthesia（T₀）and 30minutes（T₁）,1hour（T₂）,and 2hours（T₃）after anesthesia,the following indicators were measured:blood glucose（Glu）,cortisol（Cor）.ResultAll indicators of patients before anesthesia were comparable,there were no significant differences;Hemodynamic changes:SBP and DBP of two groups were decreased signi-ficantly at T₁,T₂（P<0.05）,and the difference of SBP had a statistical significance（P<0.05）,at T₁,group A>group B,at T₂,group B>group A,compared with group A,SBP,DBP,HR of group B at T₁,T₂,T₃,standard deviation all had increased to some extent.Compared with that of T₀,Glu Cor concentration of T₁,T₂,T₃,in two groups patients all increased significantly（P<0.05）.Two group patients were compared between two groups,the difference of Glu,Cor concentration had statistical significance at T₁,T₂,T₃（P<0.05）,group B>group A.ConclusionsDexmedetomidine can reduce blood sugar and the degree of stress reaction in the elderly patients with type 2 diabetes under general anesthesia and colorectal cancer surgery.And it can obtain effective sedation stable hemodynamics in patients.