Analysis On Nutritional Status Of Vitamin D In Children With Short Stature

Objective:To explore the nutritional status of vitamin D in children with different genders,ages and types of short stature.Methods:From September 2014 to December 2018,1570 children with a short stature diagnosed by the Department of Endocrinology and Metabolism,Children’s Hospital of Kunming,were selected.The groups are as follows:1.According to gender,male children group(862 cases)and female children group(708 cases);2.Age group divided into preschool group(545 cases),school age group(775 cases)and adolescence Group(219 cases);3.According to the short stature type,it was divided into idiopathic short group(906 cases),growth hormone deficiency group(609 cases),small gestational age group(40 cases),and familial short stature group(15).example).Retrospective analysis of the differences in serum 25-hydroxyvitamin D3(25(OH)D3),alkaline phosphatase(ALP),serum calcium(Ca),phosphorus(P)concentrations between groups,further explore different genders,different Nutritional status of vitamin D in children of different ages and types of short stature.Results:1.Comparison of vitamin D nutritional status between male short stature children and female short stature children:According to the Mann-Whitney test,male Dwarf children have lower vitamin D deficiency and deficiency than female short stature children.(Z=-3.568,P<0.05),suggesting that in children with short stature,female children are more prone to vitamin D deficiency and deficiency than male children.2.Pairwise comparison of vitamin D nutritional status in children with short staging of all ages,according to the Mann-Whitney test:(1)Preschool children with short stature have a lower proportion of vitamin D deficiency and less than the school age Children with short stature(Z=5.800,P<0.01)and children with adolescent dwarf(Z=6.718,P<0.01);(2)Children with school-age dwarf were lower in vitamin D deficiency than those with adolescent dwarf Children(Z=2.787,P<0.05,),that is,the distribution of the three age groups were different,and the preschool children with short stature had the highest proportion of vitamin D.3.According to the Kruskal-Wallis test,there was no significant difference in the distribution of vitamin D nutritional status among children with different types of short stature(H=7.836,P=0.098).4.Comparison of serum 25(OH)D3,AKP,Ca,and P levels in growth hormone deficiency(GHD)and idiopathic short children(ISS):According to t test,serum Ca level in children with GHD is higher than that in children with ISS(P<0.05),AKP level was lower than ISS(P<0.05).There was no significant difference in serum 25(OH)D3 and AKP between the two groups(P>0.05).5.Serum 25(OH)D3,ALP,Ca,and P levels in children with different ages of GHD:According to analysis of variance,serum 25(OH)D3 and ALP levels in children with preschool GHD were higher than those in children with pubertal GHD.(P<0.05),serum 25(OH)D3 levels in children with preschool GHD were higher than those in school-age GHD(P<0.05),and there was no significant difference in Ca and P levels between children of GHD in all ages.(P>0.05).6.Serum 25(OH)D3,ALP,Ca,and P levels in children with different ages of ISS:serum 25(OH)D3,ALP levels in preschool children with ISS were higher than those in school age and adolescent ISS(P<0.05),serum ALP levels in children with ISS were higher than those in school-age children with ISS(P<0.05),and there was no significant difference in Ca levels between children with ISS at different ages(P>0.05).Conclusions:1.Vitamin D deficiency in children with short stature is gender-specific,that is,women with short stature are more likely to develop vitamin D deficiency than children with dwarfs.2.Preschool children with short stature have the best nutritional status of vitamin D,which is consistent with the fluctuation trend of children’s skeletal development and physical growth,and is considered to be related to the increase of outdoor sports in preschool children.School-age,adolescent short-term children are more prone to vitamin D deficiency than pre-school children with short stature,so clinical work should pay more attention to monitoring vitamin D levels in school-age,adolescent short-term children,while paying attention to vitamin D supply.3.Growth hormone deficiency and idiopathic shortness are more common in children with short stature.Compared with the two,idiopathic short children are more likely to develop low calcium and high phosphorus.It is speculated that children with idiopathic short stature may have imbalance of calcium and phosphorus.Causes bone mineralization to be blocked,affecting bone development,and thus affecting children’s height.