Study On The Correlation Between Early Rehabilitation Therapy And The Prognosis Of Motor Function In Acute Stroke

Objective:To investigate the effect of exercise rehabilitation within 48 hours on the prognosis of motor function in patients with acute ischemic stroke（AIS）.Methods:We enrolled 82 cases of AIS from Emergency Department and Neurology Ward,Shengjing Hospital of China Medical University from April 2016 to August2018 and randomized them into group A（n=41）,and group B（n=41,3 patients withdrew from the study）,receiving an exercise rehabilitation initiated within 24-48h,48-120 h,respectively after the onset of AIS.The intervention for both groups ended on the 90th day after the onset of AIS.The function was evaluated by Modified Rankin Scale（MRS）and Fugl-Meyer Assessment（FMA）on the 30th,60th,and 90th days after the onset of AIS,respectively.National Institute of Health stroke scale（NIHSS）was evaluated on the 90th day.Results:Two groups showed no significant differences in baseline characteristics and all measured scores after the onset of AIS（P>0.05）.Group A demonstrated a significantly decreased mean MRS score on the 60th and 90th day after the onset of AIS（P<0.05）.The number of patients with MRS 0-2 score in group A was significantly higher than that in group B on 90th day（P=0.02,OR 3.40;95%CI1.15-10.10）.The overall mean lower extremity FMA score and mean lower extremity FMA score at different times during the rehabilitation period differed significantly between the groups（P<0.05）.Although the overall mean upper extremity FMA score did not differ significantly between the groups（P>0.05）,the mean upper extremity FMA score varied substantially between the groups at different times during the rehabilitation period（P<0.05）.In addition,the FMA scores for both the upper and lower extremities were not influenced obviously by the interaction effect of the timing of initiating exercise rehabilitation and duration of the rehabilitation（P>0.05）.Two groups showed no significant differences in NIHSS score on the 90^thday after the onset of AIS.No adverse events occurred in both groups.Conclusion:For AIS patients with an MRS score of 3-4,exercise rehabilitation initiated within 48 h after the onset of AIS can significantly improve the ability of daily life and the lower limb motor function.