Clinical Value Of Delayed-enhancement MRI In Evaluating The Prognosis Of Surgical Ablation In Patients With Atrial Fibrillation

Objective To investigate the value of Delayed Enhancement MRI(DE-MRI)in evaluating the prognosis of surgical ablation in patients with atrial fibrillation(AF)and the relationship between DE-MRI and histopathology examination.Methods From October 2013 to December 2015,43 AF patients undergoing surgical ablation got DE-MRI before the surgery and were devided into three groups according to the extent of atrial fibrosis.With the surgical occlusion process,the left atrial appendages were taken to histopathology examination,RT-PCR and immunohistochemical examination.We analyzed the relationships between DE-MRI and other examinations.Patients were followed-up for more than 1 year.Results The results of DE-MRI were correlated with the histopathology examinations(r=0.69,0.48,0.65,0.51,0.47,0.52,P<0.05);the sinus rhythm keeping rate in 1 year of the moderate-enhancement group was much higher than the unusual-enhancement group(83.3% vs 52.6%,P<0.05).Conclution DE-MRI can be used to detect the extent of the atrial fibrosis and late enhancement area over 35% suggests poor prognosis.