Study On The Correlation Between 25 - Hydroxy Vitamin D And Recurrent Respiratory Tract Infection

Objective: To investigate the correlation between 25-(OH)-D and recurrent respiratory tract infection.Methods: Choose from October 2016 to January 2017 during this period,Ningbo City,Zhejiang Province Yinzhou People’s Hospital RRI in children with pediatric hospitalization in 120 cases of experimental group,Choose the same period 120 cases of children in the control group,In addition,the children in the recurrent respiratory tract infection group were randomly divided into two groups: the vitamin D group and the untreated group.The general data of the two groups were compared,including the sex,age and body weight.Compared to the levels of serum 25-(OH)-D in the two groups.The levels of immunity indexes and the peripheral blood lymphocyte subsets of the two groups were compared.In the experimental group,compared with the untreated group,the number of respiratiory infections and the clinical efficacy were compared;The levels of immunity indexes and the peripheral blood lymphocyte subsets were compared before and after treatment.Results:(1)There was no significant difference in serum 25-hydroxyvitamin D levels among different sexes(P>0.05);(2)The serum levels of 25-hydroxy vitamin D in infants aged 3-5 years and 6-10 years old were significantly higher than those of infants aged 6 months to 1 year old(excluding)and 1-2 years old(P<0.05);(3)The adequacy ratio in the control group was significantly higher than that in the experimental group,and the deficiency rate was significantly lower than that in the experimental group(p <0.05);(4)The 25-hydroxyvitamin D in the experimental group was significantly lower than that in the control group(p<0.05);(5)In the experimental group,after treatment,the number of respiratory infections in the vitamin D group was significantly lower than that in the non-addition group(p<0.05).25-(OH)-D was found in the vitamin D group was significantly higher than the non-addition group(p<0.05);(6)In the experimental group,the total effective rate of the vitamin D added group was significantly higher than the non-addition group(p<0.05);(7)After treatment,the Ig G,Ig A,and Ig M levels of vitamin D added group were significantly higher than those in the non-addition group(p<0.05).Before treatment,the Ig G,Ig A,and Ig M in the vitamin D-added group and the untreated group were significantly lower than those in the healthy control group(p<0.05).(8)After treatment,CD3+,CD4+,and CD4+/CD8+ in the vitamin D-addition group were significantly higher than those in the vitamin D-unaddition groupp(p<0.05).Before treatment,the levels of CD3+,CD4+ and CD4+/CD8+ in the healthy control group were significantly higher than those in the experimental group(p<0.05).(9)Logistic regression analysis of the relationship between 25-OH-D levels in children with recurrent respiratory infections and the risk of recurrent respiratory infections found that for every 25-OH-D increase in l nmol/L,the risk of recurrent respiratory infections was 0.948 times.Conclusion:(1)The nutritional status of male and female vitamin D in children with respiratory tract infection is close;(2)The lack of serum 25(OH)D and recurrent respiratory tract infection have a correlation;(3)The levels of Ig G,Ig A and Ig M in patients with recurrent respiratory tract infection were lower than those in normal children.The decrease of Ig G,Ig A and Ig M was related to the deficiency of vitamin D.(4)RRI is closely related to the decrease of lymphocyte subsets.(5)To add vitamin D can effectively regulate the immune function,reduce the incidence of respiratory infections.