| Objective:To evaluate the systematic approach of evidence-based medicine literature on all resting state functional magnetic resonance imaging study of ischemic stroke technology,in order to provide the basis for clinical evidence-based medicine.Methods:We searched:PubMed,Embase,ScienceDirect,ChineseBiomedical Literature Database(CBMDisc),CNKI,WanFang Data and VIP database manually supplementary search based on resting-state functional magnetic resonance patients with ischemic brain function and brain structure important meetings and stroke Archive data set,all searches are as of December 2015.The researchers screened by the two separate documents,data extraction,if opinions diverge,the third person involved in discussions.According to the design of"data extraction form"into the literature of basic information,including the name of the article,author,year of publication,source,laterality index(LI),the number of activated voxels in the region of interest,bilateral sensorimotor area(SMC),partial coherence(ReHo),Fugl-Meyer score,region of interest(ROI)analysis,bilateral supplementary motor area(SMA),the primary motor cortex(M1),MoCA score,etc.,and of used literature number order.Reference Cochrane systematic reviews of RCT’s Manual 5.1 The risk of bias assessment tool offset risk assessment included studies by two reviewers independently for each of the following entry to"high","low","unclear"evaluation.For meta-analysis software RevMan5.3 and stata13.1.Count data using relative risk(RR),said continuous variables using standardized mean difference(SMD),said both calculated 95%confidence interval(95%CI).I~2 is determined by the value of the heterogeneity of the included studies,with P<0.05 as statistically significant.Results:The study included 20 RCTs in the meta-analysis showed that:(1)resting state of brain death group PMC region was significantly less than the control group(SMD=-1.09,95%CI[-1.63,-0.55]),differences in study after each merger was statistically significant(Z=3.98,P<0.00001);(2)resting state of brain death was significantly lower ReHo group M1 zone is less than the control group(SMD=-0.62,95%CI[-1.09,-0.14]),differences in study after each merger was statistically significant(Z=2.52,P=0.001);(3)under resting state ReHo value of stroke group SMA region was significantly less than the control group(SMD=0.65,95%CI[0.25,1.04]),differences in study after each merger was statistically significant(Z=3.23,P=0.001);(4)the LI of brain hemisphere stroke group was significantly less than the control group(SMD=-1.25,95%CI[-2.09,-0.42]),after various research merge difference was statistically significant(Z=2.95,P=0.003);(5)the LI of SMC stroke group was significantly less than the control group(MSD=-1.3,95%CI[-1.76,-0.84]),differences in study after each merger was statistically significant(Z=5.57,P<0.00001);(6)the LI of SMA stroke group was significantly more than the control group(SMD=1.34,95%CI[0.65,1.61]),differences in study after each merger was statistically significant(Z=5.17,P<0.00001);(7)after brain death group training on the brain during cognitive obstacle to improving understanding of the role and the control group fairly(SMD=0.069,95%CI[-1.29,1.43]),the difference after the merger of each study was not statistically significant(Z=0.10,P=0.92);(8)the motor area brain stroke group was significantly improved through the training(SMD=2.8,95%CI[1.56,2.54]),each of the Merger after the difference was statistically significant(Z=8.19,P<0.00001);Conclusion:Based on the current experimental evidence,in the resting state,compared with the control group,the ReHo in the case group showed decrease in the M1、PMC、SMC,the LI in the case group showed less in brain hemisphere、SMC.Moreover,compared with the control group,the ReHo and LI of SMC in the case group showed increased.Combined with the results of Fugl-Meyer motor function score,it is speculated that this is related to the recovery of motor function in patients. |
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