| Objective To study the influence of ultrasound-guided serratus plane(SP)block on metastasis and recurrence of breast cancer after modified radical mastectomy.Methods Sixty patients received selected modified radical mastectomy between July2014 and July 2015 were enrolled in this study.The patients were randomly divided into two groups: SP block group(group S)and control group(group C),30 patients respectively.Two groups received ultrasound-guided SP block after anaesthesia induction,group S received 0.5% ropivacaine injection and group C received saline.The concentration of serum IL-10,MMP-2 and MMP-9 were tested 30 minutes before surgery(T0),3 hours after surgery(T1)and 24 hours after surgery(T2).Results The trend of IL-10,MMP-2,MMP-9 were significantly increased at T1,T2(P<0.05).The concentration of IL-10 in group S were significantly higher than in group C at T1,T2(P<0.05).The concentration of MMP-2,MMP-9in group S were significantly lower than in group C at T1,T2(P<0.05).Conclusion Ultrasound-guided SP block can effectively decrease the immune function of breast cancer after modified radical mastectomy. |
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