Dynamic Influence Of Short Term To Very High-altitude On Clinical Indexes For People From Plain

Objective: To explore the dynamic influence of short term to very high-altitude on relevant symptoms and physiological for people from plain.Methods: A follow-up study was conducted on The Support Tibetan Team of Liaoning Province.The team flew from the Shenyang(50m)to Lhasa(3658m,1d rest)via Chengdu,and the passenger car went to Nagqu(4507m).Record the relevant symptoms of the respondents and blood pressure,heart rate,arterial oxygen saturation and other indicators at different altitudes and at different time points.According to the symptom scores and scores in China,the symptoms of the respondents were scored to confirm whether they had acute altitude sickness.Results:(1)A total of 67 people were enrolled,including 55 males and 12 females.At3658 m above sea level,45(67.2%)were diagnosed with AMS,mainly with headache(62.7%),dizziness(52.2%),and sleep disorders(37.3%),gastrointestinal symptoms(35.8%),palpitation(34.3%)and chest tightness(25.4%),one of them was suspected of cerebral edema,and one was due to frequent ventricular premature beats and returned to the plain.(2)At 4507 m above sea level,46 people(70.8%)were diagnosed with AMS,mainly including headache(69.2%),sleep disorders(40.0%),gastrointestinal symptoms(36.9%),dizziness(30.8%),and palpitation(29.2%)and chest tightness(27.7%),one of them was unable to tolerate the symptoms of chest tightness due to anemia and returned to the plain.Compared with 3658 m above sea level,the incidence of AMS increased to4507 m,but there was no statistical significance(p>0.05).The incidence of symptoms was significantly lower than that of dizziness(p=0.012).There was no significant difference in the incidence of other symptoms(p>0.05).(3)After entering the very high-altitude,with the prolongation of time,the incidence of chest tightness gradually increased(p>0.05),and the incidence of other symptoms decreased gradually;headache and sleep disorders decreased after 2 to 3 days,but did not disappear,digestive tract symptoms and dizziness disappeared after 5 to 6 days.(4)From the plain through Lhasa to Nagqu that day,the systolic and diastolic blood pressures of the supportive Tibetans increased significantly[(125.01±10.65)mm Hg,(131.21±10.47)mm Hg,(141.63±12.44)mm Hg,(73.67±7.81)mm Hg,(80.48±7.72)mm Hg,(87.29±9.94)mm Hg,F=36.949,F=42.030,all p<0.05)],the heart rate increased significantly[(76.27±8.29)bpm,(83.34±8.58)bpm,(90.74±9.48)bpm,F=44.671,p<0.05)],and the arterial oxygen saturation decreased significantly(96.72%±1.22%,87.13%±3.46%,85.00%±2.9%,F=352.336,p<0.05).After entering Nagqu,the systolic blood pressure,diastolic blood pressure and heart rate returned to the plain level on the 6th,8th,and 6th,respectively,as the time of acclimatization prolonged,but the arterial oxygen saturation was always lower than the plain level.Conclusion: People from plain moving into the very high-altitude are prone to AMS,mainly manifested as headache,sleep disorders,gastrointestinal symptoms,dizziness,palpitation and chest tightness,but with the extension of time,headache,sleep disorders,gastrointestinal symptoms and dizziness gradually reduce or disappear blood pressure and heart rate can be restored to the plain level,but arterial oxygen saturation is always lower than the plain level.