Clinical Significance Of Blood Basophil Count And Eosophil-to-basophil Ratio In Peripheral Blood Of Pediatric Patients With Atopic Dermatitis

Background:Basophil is a kind of important effector cell in many allergic diseases including atopic dermatitis.At present,there are relatively few studies about basophil counts and blood eosphil-to-basophil ratio in peripheral blood of atopic diseases.It is not clear whether the counts of basophil and blood eosinophil-to-basophil ratio in peripheral blood of pediatric patients with AD is different from that of normal children.Objective : The aim of this study is to detect the counts of basophil and eosinophil-to-basophil ratio in peripheral blood of pediatric patients with AD,to evaluate whether basophil counts or blood eosinophil-to-basophil ratio could be a potential indicator of the severity of AD.Methods:In this study,493 children under 6 years old with AD and 302 normal children were selected.Peripheral blood samples were collected and the basophil counts,serum total Ig E level,eosinophil counts were measured.The O-SCORAD was used to assess the severity of AD according to clinical manifestations.The data were compared among basophil,eosinophil,b Eo/B and serum total Ig E levels by age groups,the correlation between them and O-SCORAD also analyzed.Results:1.The basophil counts in peripheral blood of pediatric patients with AD had no significant difference between all age groups,there is no significant correlation between the basophil counts and O-SCORAD score;the b Eo/B and eosinophil counts in peripheral blood of children aged 0-6 years were higher than those of normal children;the total Ig E level in serum of pediatric patients with AD in 7-12 M group had no significance,and the total Ig E level in other age groups was higher than that of normal children.2.In 0-6M group,the levels of b Eo/B,eosinophil counts and serum total Ig E were positively correlated with O-SCORAD score,while in 7-72 M group,the levels of b Eo/B,serum total Ig E and eosinophil counts are no significantly correlated with O-SCORAD score.Conclusion:1.There is no significant difference in basophil counts between pediatric patients with AD under 6 years old and normal children,and there was no significant correlation between basophil counts and disease severity.2.The levels of b Eo/B,serum total Ig E and eosinophil in pediatric patients with AD less than 6 years old were higher than those in normal children;in pediatric patients with AD less than 6 months old,b Eo/B,eosinophil counts and serum total Ig E can be used as indicators of disease severity.