Study On The Correlation Between Plasma Soluble Sema4D Level And Heart Failure With Chronic Reduced Ejection Fraction

Objective: Analysis of the heart failure of chronic lower left entricular ejection fraction(HFrEF)in patients with plasma soluble signal element concentrations of 4 d(Sema4D)the difference with the healthy controls and patients with chronic heart failure plasma soluble Sema4 D and N terminal brain natriuretic peptide hormone level of the original(NT-ProBNP),New York,cardiac function classification(NYHA classification),left ventricular ejection fraction(LVEF),left ventricular end systolic volume(LVESV),left ventricular end systolic volume(LVEDV),To evaluate the clinical value of plasma soluble Sema4 D in the diagnosis of chronic heart failure and its severity.Methods: In this study,158 patients with heart failure who met the inclusion criteria for chronic ejection fraction reduction were selected,including 34 patients with grade II heart function,55 patients with grade III heart function,and 68 patients with grade IV heart function,including 62 males and 96 females.At the same time,152 age-matched healthy subjects admitted to hospital at the same period were selected as the control group,including 68 males and 84 females.The plasma soluble Sema4 D concentration,plasma nt-probnp concentration and echocardiographic index:LVEF: left ventricular ejection fraction were determined by elisa.LVEDV: left ventricular end-diastolic volume;LVESV: left ventricular end-systolic volume.ROC curve was used to evaluate the value of plasma soluble Sema4 D in the diagnosis of HFrEF,and Spearman correlation analysis was used to analyze the correlation between plasma soluble Sema4 D,nt-probnp level,NYHA grade,left ventricular ejection fraction(LVEF),left ventricular end-systolic volume(LVESV),and left ventricular end-systolic volume(LVEDV),respectively.Patients with different severity of HFrEF were grouped by cardiac function grading in New York,and the plasma soluble Sema4 D level of patients with different cardiac function grading was evaluated by one-way anova.Results:(1)Compared with the healthy control group,the erythrocyte count(RBC),hemoglobin(HGB)and albumin(ALB)of the chronic heart failure patients with lower ejection fraction decreased,while the white blood cell count(WBC),alanine aminotransferase(ALT),creatinine(Scr),urea nitrogen(BUN)and uric acid(UA)increased in the chronic heart failure patients with lower ejection fraction.There was significant difference between the two groups(P < 0.001).ROC curve analysis showed that the diagnosis of chronic heart failure with lower ejection fraction had reference value;(2)Spearman correlation analysis showed that plasma soluble Sema4 D concentration,left ventricular ejection fraction(LVEF),left ventricular end systolic volume(LVESV),left ventricular end diastolic volume(LVEDV)were in NYHA II,N.There were significant differences between YHA III and NYHA IV groups(P < 0.001).With the decline of cardiac function,plasma soluble Sema4 D concentration and NT-proBNP level increased.Conclusions: plasma soluble Sema4 D is highly valuable in the diagnosis of chronic ejection fraction depression in heart failure,and plasma soluble Sema4 D is positively correlated with the severity of heart failure.