Correlation Study Between Intestinal Microecological Structure,Personality,Cognitive Emotion Regulation And Depression

Objective To understand the differences in intestinal microflora structure,personality characteristics,and cognitive emotion regulation between patients with depressive disorder and healthy people,correlating physiological and psychological factors,so as to further explore the mechanism of depression development.Methods Thirty patients with depression from 18 to 50 years old in Ningxia were enrolled,and 31 healthy people with general conditions were matched.The fecal collection and the assessment of a general questionnaire,the Hamilton Depression Scale,the Eysenck Personality Questionnaire(EPQ),and the Cognitive Emotion Regulation Questionnaire(CERQ)were completed.High-throughput sequencing and bioinformatics methods were used to analyze the diversity of microbial flora.Non-parametric tests were used to compare the psychological assessment results of the two groups,and correlation and regression analysis were used to examine the interaction of intestinal flora,personality,cognitive emotion regulation,and depression.Results There was no significant difference in the diversity of intestinal microflora between patients with depression and healthy people(p>0.05).However,the intestinal microbiota diversity of the mild to moderate depression group was higher than the healthy control group,and the diversity of the severe depression group was lower than that(p<0.001).Compared with the control group,the abundance of intestinal flora in the depression group was significantly different in the levels of the phylum,the class,the order,the family and the genus,which was statistically significant.At the level of phylum,compared to the control group,the abundance of the Firmicutes,Actinobacteria,and Tenericutes(p<0.05)of the case group decreased significantly,and the Bacteroidetes(p<0.05)increased significantly.At the level of genus,the case group had lower relative abundance of Ruminococcus(p<0.01)、Subdoligranulum(p<0.01)、Enterobacter(p<0.05)、Coprococcus(p<0.05)、Bifidobacterium(p<0.05)、Lactobacillus(p<0.05)and Mitsuokella(p<0.05),and higher abundance of the Bacteroides(p<0.01)and Flavonifractor(p<0.05)than the controls.The neurotic scores of patients with depressive disorder were significantly higher than those of healthy controls.At the same time,depressed patients tend to adopt cognitive emotion regulation strategies such as self-blame,rumination,and catastrophe when they encounter negative events.The severity of depression was positively correlated with the relative abundance of Bacteroides(r=0.569,p<0.01)and Flavonifractor(r=0.387,p<0.05),and negatively correlated with various Butyrate-producing bacteria.Neurotic personality traits(β=0.503,p<0.01),self-blame(β=0.401,p<0.05),rumination(β=0.369,p<0.05),and the reduction of Faecalibacterium and Coprococcus has a predictive effect on the development of depression.Conclusion There are significant differences in intestinal micro-ecological structure,personality traits,and cognitive emotion regulation strategies between patients with depressive disorder and healthy controls;neurotic personality traits,self-blame,rumination,and the reduction of Faecalibacterium and Coprococcus has a predictive effect on the development of depression.