| ObjectiveTo investigate whether liver product prescription has inhibitory effect on liver can-cer and its mechanism.MethodsAll the cases collected will be 50 cases,of which 20 cases of Western medicine group will be treated with Western medicine.Chinese medicine+Western medicine group 15 cases to Western medicine+Chinese medicine liver product prescription treatment;In the Chinese medicine group,15 cases were treated with traditional Chinese medicine liver prescription(composition:Bupleurum12g,Paeoniae Alba10 g,Atractylodes10g,Codono-psis30 g,Pinellia pilosa30 g,Astragalus10g,Astragalus30 g,Diptera10g,Licorice6 g,can be added and reduced with evidence.The above is 1 dose,Make 400 ml soup,1 dose per day,200 ml each morning and evening,3 months of treatment).Basic experiment:30 mice were used to establish the model of tumor formation in situ liver cancer,and the model was successfully molded in 10 d.The 30 liver cancer mice that were successfully m-olded were randomly divided into four groups:IL-1group(8),liver product group+IL-1 g-roup(8),liver product group(8),and blank group(6),continuous administration for 10 days,Daily weight measurement,observation of mice eating,drinking water,mental state,activity,fur color and death,etc.,to record.The ELISA method detects IL-8 and IL-10.ResultsClinical part:1.The age,sex and imaging of the patient were not statistically signi-ficant(P Both larger than0.05);2.Compared with KPS score of each group of patients,the Western medicine group,Chinese medicine group,and Chinese medicine group had a statistically significant difference after treatment and before treatment(P both smaller than 0.05),and the Chinese medicine group+Western medicine group and Chinese med-icine group were more significant;The difference was statistically significant among th-e three groups of Western medicine group,traditional Chinese medicine group and trad-itional Chinese medicine group after treatment(P less than 0.05).3.Comparing the clini-cal symptoms of each group of patients,the treatment of traditional Chinese medicine+Western medicine group and traditional Chinese medicine group were all lower than before treatment,and the difference was statistically significant(P both smaller than 0.05)4.Comparison of Child-pugh classification in each group of patients with clinical liver function,the difference between Western medicine group,traditional Chinese medicine g-roup,and traditional Chinese medicine group after treatment and before treatment was statistically significant(P Both larger than 0.05);The difference was statistically significa-nt before and after the treatment of Chinese medicine+ Western medicine group and Chinese medicine group(P both smaller than 0.05).5.There was no statistically significa-nt difference between the three groups of patients with AFP(P Both larger than 0.05);There was no significant difference between the three groups before and after treatmen-t(P Both larger than 0.05);6.The concentration of serum IL-10 ELISA in each group of patients was significantly lower than that before treatment after treatment in three g-roups:Western medicine group,Chinese medicine group,and Chinese medicine group.Th-e difference was statistically significant(P both smaller than 0.05).7.The concentration of serum IL-8 ELISA in each group of patients was significantly lower than that befo-re the treatment after the treatment of Western medicine group,Chinese medicine grou-p,and Chinese medicine group.The difference was statistically significant(P both smalle-r than 0.05).Basic experimental part:1.Comparison of serum weight in each group of mice,and comparison between the four groups before and after treatment,there was no statistica-l difference(P Both larger than 0.05);2.There was a statistically significant difference between the concentrations of IL-10 and IL-8 ELISA in the blank group,the Chinese medicine+IL-1 group,the IL-1 group and the Chinese medicine group(P less than 0.05);The difference was statistically significant before and after the treatment of Chinese m-edicine+IL-1 group and Chinese medicine group(P both smaller than 0.05).ConclusionHepatic product can inhibit the progress of liver cancer,which may be achieved b-y reducing the expression levels of inflammatory factors IL-8 and IL-10,and then acti-ng to inhibit the inflammatory response of the liver and reduce the continuous stimul-ation of liver parenchyma cells by the inflammatory microenvironment.the overall inte-rvention effect of liver and spleen deficiency and blood stasis was brought into play to improve the clinical symptoms of primary liver cancer patients with liver and splee-ndeficiency and blood stasis and improve the quality of life. |
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