| Objective:Through the holistic view of traditional Chinese medicine,dialectical treatment and the advantages of modern science and technology,starting from the pathogenic mechanism of post-infection cough,the clinical efficacy of Wenfeijian in treating post-infection cough due to cold-pathogenic pulmonary infection is observed.The feasibility and advantages of traditional Chinese medicine in treating post-infection cough are further verified through cough symptom scores,cough visual simulation scores,traditional Chinese medicine symptom scores and cough sensitive experimental observation indicators,so as to enrich the clinical experience of traditional Chinese medicine in treating post-infection cough,improve the efficacy,improve the quality of life of patients,and produce good economic and social benefits.Method:The clinical trial design is divided into random control groups with a total sample size of 80 cases.the treatment group and the control group are divided into 2 groups randomly according to a ratio of1:1.the collected cases are screened into the group.cough sensitivity tests and cough symptom scores,cough visual analog scores,TCM symptom scores and related indexes are calculated on the first and seventh days of initial diagnosis.spss22.0 is used for statistical analysis,and the treatment group and the control group,the two groups before and after treatment,and between groups are analyzed and compared,P<0.05,with statistical significance and difference.Result:From the experimental data,it can be seen that gender,age and course of disease P>0.05,which is not statistically significant,indicating that there is no significant difference between the two groups of patients and they are comparable.After treatment,the total curative effect of the two groups was compared by rank sum test,Z=-3.236,P=0.001<0.01,with statistical significance and difference,indicating that wenfei decoction has higher clinical total curative effect than compound pseudoephedrine capsule in treating cough after cold-pathogenic pulmonary infection.The daytime scores before treatment in the two groups were tested by chi-square test,?~2=5.085,P=0.279>0.05.the nighttime scores before treatment in the two groups were tested by chi-square test,?~2=2.251,P=0.813>0.05.the total daytime and nighttime scores in the two groups were tested by chi-square test,?~2=4,P=0.261>0.05.the total cough scores before treatment in the two groups were tested by independent sample t,t=0.567.P=0.567>0.05.the cough degree before treatment in the two groups was tested by rank sum test Z=-0.549,P=0.583>0.05.the cough,expectoration,aversion to cold and pharyngeal itching symptoms in the two groups were tested by independent samplet before treatment.the cough symptoms t=0.434,P=0.665,expectoration t=-0.15,P=0.88,aversion to cold t=0.57,P=0.57,pharyngeal itching t=-0.42,P=0.68.All the above symptoms P>0.05.before treatment,C2 and C5 in the two groups were tested by independent samples t,C2 treatment group and C2 control group,t=-0.058,P=0.954>0.05,C5 treatment group and C5 control group,t=-0.320,P=0.750>0.05,above p>0.05,with no statistical significance and comparability.One week after treatment,the daytime score after treatment in the two groups was tested by chi-square test,?~2=11.817,P=0.019<0.05.the nighttime score after treatment in the two groups was tested by chi-square test,?~2=15.024,P=0.010<0.05.the total score of cough symptoms after treatment in the two groups was tested by independent sample t,t=-2.216,P=0.03<0.05.the total score of cough before and after treatment in the two groups was tested by paired t test.t=10.72,P=0.000<0.01 before and after treatment in the treatment group,t=8.74,P=0.000<0.01,p<0.01 before and after treatment in the control group,with statistical significance,indicating that there is significant difference between the two groups before and after treatment,and both groups can reduce the cough total score.After treatment,the total score of cough symptoms in the two groups was tested by independent sample t,t=-2.216,P=0.03<0.05,with statistical significance and difference,indicating that the total score of cough symptoms in the treatment group is better than that in the control group.The cough degree before and after treatment in the two groups is compared.the paired t test before and after treatment in the treatment group,t=11.61,P=0.000<0.01,t=9.54 in the control group,P=0.000<0.01,P<0.01,with statistical significance,indicating that there is significant difference between the two groups before and after treatment.both groups can reduce cough degree.the cough degree after treatment in the two groups is tested by rank sum test,Z=-2.193,P=0.028<0.05,above P<0.05,with statistical significance and difference,respectively indicating that the treatment group can reduce cough degree compared with the control group Paired T test before and after intra-group treatment was carried out on cough of main symptom,expectoration of secondary symptom,aversion to cold and pharyngeal itch in TCM symptom score.Cough symptom score t=9.05,P=0.000 before and after treatment in treatment group,t=6.21,P=0.000 in control group;Before and after treatment,expectoration score t=8.12,P=0.000 in the treatment group,t=6.96,P=0.000 in the control group,aversion to cold score t=13.08,P=0.000before and after treatment in the treatment group,t=9.41,P=0.000 in the control group;Before and after treatment,pharyngeal itch score t=13.44,P=0.000 in treatment group,t=10.82,P=0.000 in control group;The above four symptom scores of the two groups before and after treatment were statistically significant(P<0.01),with differences,indicating that the two groups can improve the symptoms of cough,expectoration,aversion to cold and pharyngeal itching.After treatment,the TCM symptom scores of the two groups were tested by independent samples T.Cough symptom t=-2.1,P=0.036,expectoration t=-2.63,P=0.01,aversion to cold t=-3.21,P=0.002,pharyngeal itch t=-4.38,P=0.000;After treatment,the above symptoms in the two groups were all p<0.05,with statistical significance and difference.this shows that the treatment group is better than the control group in improving cough,expectoration,aversion to cold and pharyngeal itch,and the treatment group has significant difference in aversion to cold and pharyngeal itch P<0.01,which shows that the treatment group has more significant improvement in aversion to cold and pharyngeal itch.Before C2 in treatment group,C2was tested by paired t,t=-8.046,p=0.000<0.01;Before C2 in the control group,C2 was tested by paired t test,t=-5.829,P=0.000<0.01,with statistical significance and significant difference,indicating that C2 value can be increased in both the treatment group and the control group.Before C5 and after C5 in the treatment group,paired t test showed that t=-8.046,p=0.000<0.01;The paired t test before C5 and after C5 in the control group showed that t=-5.829,P=0.000<0.01,with statistical significance and significant difference,indicating that both the treatment group and the control group can increase the C5 value.The above comparison between C2 and C5 in the two groups shows that both groups can reduce cough sensitivity of PIC patients.After treatment,C2 and C5 in the two groups were tested by independent sample t,C2treatment group and C2 control group,t=4.314,p=0.000<0.01;C5treatment group and C5 control group,t=4.672,P=0.000<0.01,P<0.01,with statistical significance and significant difference,indicating that the treatment group is better than the control group in improving cough sensitivity of PIC patients.Conclusion:1 Wen Fei Jian is superior to the control group in the total clinical effect of treating PIC of cold-pathogenic pulmonary infection,and is superior to the control group in"improving"the disease condition.2 Wen Fei Jian and compound pseudoephedrine sustained-release capsules can improve cough symptom score,cough degree,TCM symptom score and cough sensitivity.3 Wen Fei Jian is more obvious than compound pseudo ephedra sustained-release capsule in reducing cough symptom scores,especially at night.4 Wen Fei Jian is more obvious in reducing cough grade(cough visual score)than compound pseudo ephedra sustained release capsule.5 Wen Fei Jian is better than compound pseudoephedrine sustained-release capsule in reducing TCM symptoms(cough,expectoration,aversion to cold,pharyngeal itch)scores.6 Wen Fei Jian Compound Pseudoephedrine Sustained Release Capsule is more obvious in reducing cough sensitivity. |
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