The Correlation Of Fibrinogen And Homocysteine With Vulnerable Coronary Atherosclerotic Plaques

Objectives To explore the correlation of fibrinogen and homoc-ysteine with vulnerable coronary atherosclerotic plaques.Methods According to the inclusion criteria and exclusion criteria,there were 163 cases were selected from January 2016 to December 2017.These people had done the examination of intravascular ultrasound-virtual histology,at the same time fibrinogen and homocysteine data were integrated.According to intra-vascular ultrasound,the plaque stability was divided into stable patch group(n=33)and vulnerable plaque group(n=130).The heart rate,blood pressure,height,weight and other indicators were measured.Previous medical history was inquired and routine tests,electrocardiogram and echocardiography were improved.A database was established to input the selected data.Compared the general data and FIB and HCY levels of the two groups of patients.Finally,correlation statistical analysis was performed.The relevant indicators were processed with SPSS20.0 statistical software.The metrological data of normal distribution were expressed as mean ± standard deviation(x±S)using two independent samples of the t-test.All count data were expressed as a percentage,using chi-square test.The area under ROC curve was used to evaluate the diagnostic value of FIB and HCY for vulnerable plaques.P <0.05 was considered statistically difference.Results 1 Compared with the stable patch group,there was a statistically significant difference between the FIB and HCY levels between the two groups(P<0.05),and the FIB and HCY level were increasing in the vulnerable plaque group.2 After grouping by gender,there was a statistically significant difference in FIB between the vulnerable plaque group and the stable plaque group,both in males and females(P < 0.05).There was a statistical difference in HCY among males(P < 0.05).The mean HCY value of vulnerable plaques in women was higher than that of stable plaques,including stable plaques(11.78±4.96umol/L)and vulnerable plaques(14.79±7.93 umol /L),but the P value was > 0.05,showing no statistical difference.3 The FIB andHCY levels had predictive diagnostic value for vulnerable plaques.The best threshold for FIB and HCY to predict the of vulnerable plaques were 3.83g/L and 11.80 umol/L(the area under the ROC curve was 0.780 and0.772,respectively;the sensitivity is 68.46% and 79.23%;the specificity is 84.85% and72.73%).4 Stable and vulnerable plaques were analyzed with FIB value of 3.83g/L and HCY value of 11.80 umol/L as the boundary value.FIB and HCY are related to plaque stability.Compared with FIB<3.83g/L,FIB≥3.83g/L increases the risk of vulnerable plaque,OR(95%CI)value is 8.36(3.35-20.84).Compared with HCY<11.80 umol/L,HCY≥11.80umol/L increases the risk of vulnerable plaque,OR(95%CI)value is 7.00(3.05-16.04).5FIB value of 3.83g/L and HCY value of 11.80 umol/L as the boundary value.Sensitivity and specificity of FIB and HCY tandem for vulnerable plaques was 53.08% and90.91%.Sensitivity and specificity of FIB and HCY parallel for vulnerable plaques was90.77% and 60.61%.Conclusions 1 Fibrinogen and homocysteine levels are associated with the development of vulnerable coronary atherosclerotic plaques.2 Fibrinogen and homocysteine both have screening effects on vulnerable coronary atherosclerotic plaques,and their thresholds are3.83g/L and 11.80umol/L,respectively.3 The combination of fibrinogen and homocysteine can better evaluate coronary atherosclerotic plaques.Figure3;Table10;Reference 139...