| Objective: By designing a new temperature-controlled moxibustion jar to control the temperature of moxibustion,the thermal effect of shielding moxibustion is achieved to a certain extent.Based on the National Key Basic Research and Development Program(973Program)project “Research on Moxibustion and Phototoxic Mechanism and Its Biological Mechanism”Item number:(NO.2015CB554504).Knee Osteasritis(KOA)was used as a carrier to observe the difference in clinical efficacy between temperature-controlled moxibustion and common moxibustion.The radiation spectrum of moxibustion was used to treat clinical diseases.Method: By designing a cooling fan installed in the moxibustion tank,the air flow in the tank is realized,and the heat generated when the moxa is burned is taken away,and the thermal effect of shielding moxibustion is realized to a certain extent.Then,72 patients with KOA who met the inclusion criteria were randomly assigned to have a moxibustion group(temperature control group)and a traditional moxibustion group(ordinary group),using a multicenter,randomized,controlled clinical study method.Group of 36 cases.In both groups,the three acupoints of bilateral purging,inner knee and Zusanli were selected for moxibustion treatment,20 min each time,three times a week,once every other day,and continuous moxibustion for 12 times.Both groups used the newly developed temperature-controlled moxibustion jar for moxibustion treatment.Efficacy evaluation: Western Ontario and Mc Master Universities Osteoarthritis Index(WOMAC),Visual Analog Scale(VAS)and Clinical Cure Effectiveness were completed at 2 weeks and 4 weeks respectively.At the time of the three months after the end of moxibustion,the differences in clinical efficacy between the temperature-controlled group and the general group in the treatment of KOA were compared.Result:1.Baseline period: There was no statistical difference in the baseline data between the two groups of subjects,which was comparable.2.Evaluation of WOMAC scale:Comparison between groups: WOMAC total score,WOMAC pain score and daily activity score after 2 weeks of treatment,there was statistical difference between the temperature control group and the general group(p<0.05);other scores were compared at each time point,the differences were There was no statistical significance(p>0.05).Comparison within the group: The scores of the WOMAC scales in the temperature control group and the normal group were compared with the baseline period at 2,4,and 8weeks,and the difference was statistically significant(p<0.05).3.At the end of treatment,the overall efficacy(PGA)evaluation:Comparison between groups: After 2 weeks of treatment,the overall efficacy of the two groups was statistically significant(p<0.05).After the treatment and at the follow-up,the PGA results of the temperature control group and the normal group were not significantly different(p>0.05).Comparison within the group: PGA scores were compared between the control group and the first follow-up at 2 weeks,4 weeks,and the first follow-up.The results were statistically significant(p<0.05).PGA scores were compared between the 2nd week,4th week,and the first follow-up of the general group.The results showed no statistical difference(p>0.05).4.VAS statistics:Comparison between groups: The statistical results were between the temperature-controlled group and the KOA subjects in the general group.There was no significant difference in the decrease of the VAS scale between the 2 weeks,4 weeks,and the follow-up period(p>0.05).Comparison within the group: There was a statistically significant difference between the temperature-controlled group and the general group at the 2 weeks,4 weeks,and after the follow-up,compared with 0 weeks after enrollment(p<0.05). |