Meta-analysis Of Flurbiprofen Axetil On Preemptive Analgesia In Patients Undergoing Gynecological Laparoscopic Surgery

Objective:By using Revman software for Meta analysis,the efficacy and safety of flurbiprofen axetil on preemptive analgesia of gynecologic laparoscopic surgery was evaluated.Methods:PubMed,Cochran,Chinese biomedical CD,CNKI,VIP Journal Database,ChianInfo and other databases were searched.A randomized controlled trial of flurbiprofen axetil for preemptive analgesia in gynecological laparoscopic surgery was conducted of literature.The evaluation indexes include the adverse.Document quality evaluation and bias evaluation using Cochrane Intervention System Evaluation Manual.Reactions such as headache,dizziness,nausea,vomiting and the VAS scores of2 hours,4 hours,6 hours,8 hours,12 hours,24 hours after operation.Meta analysis was performed with Revman 5.3 Meta analysis software.Results:A total of 16 Chinese and foreign studies were included,including 1018 patients.1.Postoperative visual analogue scale score(VAS): VAS scores were statistically significant 2 hours after surgery,and VAS scores in patients with advanced analgesia were significantly lower than those of the control group [(P < 0.00001),WMD=-1.41,95%CI:-1.60~-1.23].VAS scores were statistically significant 4 hours after surgery,and VAS scores in patients with advanced analgesia were significantly lower than those of the control group[(P < 0.00001),WMD=-1.51,95%CI:-1.66~-1.36].VAS scores were statistically significant 6 hours after surgery,and VAS scores in patients with advanced analgesia were significantly lower than those of the control group[(P < 0.00001),WMD=-1.34,95%CI:-1.55~-1.13].VAS scores were statistically significant 8 hours after surgery,and VAS scores in patients with advanced analgesia were significantly lower than those of the control group[(P < 0.00001),WMD=-1.72,95%CI:-1.89~-1.55].VAS scores were statistically significant 12 hours after surgery,and VAS scores in patients with advanced analgesia were significantly lower than those of the control group[(P < 0.00001),WMD=-0.61,95%CI:-0.75~-0.48].VAS scores were statistically significant 24 hours after surgery,and VAS scores in patients with advanced analgesia were significantly lower than those of the control group[(P < 0.00001),WMD=-0.30,95%CI:-0.43~-0.17].2.Incidence of adverse reactions: The number of patients with nausea and vomiting in the preoperative analgesia group was lower than that in the control group,but it was not statistically significant [(P = 0.06),RD =-0.11,95 % CI:-0.23 ~ 0.00].The number of patients with dizziness and drowsiness in the preoperative analgesia group was lower than that in the control group,but it was not statistically significant [(P= 0.09),RR = 0.53,95 % CI: 0.25 ~ 1.10].The number of patients with pain and agitation in the preoperative analgesia group was less than that of the control group,and it was statistically significant [(P =0.003),RR=0.33,95% CI:0.16~0.69].Conclusion:Advanced analgesia of flurbiprofen axetil can relieve pain 2hours,4hours,6hours,8hours,12 hours and 24 hours after gynecological laparoscopic surgery.And does notincrease adverse reactions,such as nausea,vomiting,dizziness,drowsiness,pain and agitation.