The Value Of The Ratio Of Neutrophils To Lymphocytes In Predicting The Stability Of Coronary Plaque

ObjectivesThe purpose of this study was to explore coronary atherosclerotic heart disease in patients with blood neutrophils and lymphocytes ratio of high and low levels,to the extent of coronary artery plaque and the stability of predictive value,so as to guide clinical diagnosis and treatment of coronary atherosclerotic heart disease.Methods 1?Study patients: This study collected Tianjin Chest Hospital,Tianjin Fourth Central Hospital,Affiliated Hospital of Armed Police Logistics College from February 2015 to January 2016 due to episodes of chest pain,chest tightness and other symptoms,with coronary angiography.There were no corresponding clinical contraindications.A total of 623 patients with CHD were diagnosed by CAG.A retrospective study was performed.120 patients who underwent IVUS were from the chest hospital and the affiliated hospital of the Armed Police Logistics College.2?Study method: According to the blood routine test results for the first time after the onset of the above patients,the ratio of neutrophils to lymphocytes(NLR)was calculated according to the absolute value of neutrophils and lymphocytes,and the results were divided into T1 group(NLR <2.25),T2 group(2.25? NLR<4.51),and T3 group(NLR >4.51).Basic data including gender,age,body mass index,previous history of hypertension,diabetes,old cerebrovascular disease,smoking history and drinking history were collected.Results of systolic blood pressure,heart rate,heart function grading and first echocardiography were obtained when the patients were admitted.Intraoperative data(number of diseased vessels,SYNTAX score,etc.)were recorded according to the surgical report.The use of ACEI/ARB,beta receptor blockers,statins and other drugs during hospitalization was collected.Records of adverse events,such as AF,VT/VF,high block(AVB),heart failure(HF),cardiac shock,death,thrombus formation/then the occurrence of infarction,cerebrovascular disease,and WeChat or telephone follow-up for 3 to 6 months,record in-hospital major adverse cardiac events(MACE)(heart failure readmission,death,nonfatal myocardial infarction,ischemic stroke,etc.)what was happening.Results 1?There was no difference between the groups on gender,age,smoking history,history of drinking,BMI,hypertension,diabetes,cerebrovascular disease sequelae,body mass index,systolic blood pressure,heart function grading admission to hospital,fasting blood glucose,high density lipoprotein cholesterol,low density lipoprotein cholesterol,total cholesterol,three acyl glycerin,creatinine,red blood cell count,hemoglobin,etc.However,the heart rate,random blood glucose,TNT value,absolute value N and neutrophils in group T3 were all higher than those in group T1 and T2,while the absolute value L of lymphocytes was lower than those in group T1 and T2(P < 0.05).2?There was no statistically significant difference in coronary vascular lesions among the three groups.The variables of the T3 group were significantly higher than those of the T1 and T2 groups in terms of the two and three vascular diseases.In the T3 group,EF was low,while the utilization rate of ACEI/ARB was slightly increased.CIN 1 cases occurred in group T2 and 2 cases in group T3 There was no significant difference between T2 group and T3 group.IVUS examination was completed in 120 patients,and the analysis of the results showed that the ACS group had poor plaque stability,and the NLR statistical results were significantly higher than the SAP group,with statistical significance.3?Analysis of follow-up data showed that 3 cases of all-cause death occurred in the T3 group,higher than that in the T2 and T1 groups,but there was no statistical difference.The incidence of heart failure in the T3 group increased significantly with statistical significance.ConclusionThe ratio of neutrophils to lymphocytes(NLR)is a very easy data to obtain in clinical practice and has good stability.As a kind of inflammatory factor,it can effectively predict the condition of patients with coronary arteriosclerotic heart disease,and has good predictive value for the severity of coronary artery disease,the stability of coronary artery plaque,and the prognosis of such patients.The higher the NLR of patients with coronary atherosclerotic heart disease is,the more severe the coronary artery lesions will be.The higher SYNTAX score is,the lower the plaque stability will be.Elevated NLR is an effective indicator of poor prognosis in patients with coronary atherosclerotic heart disease.