| OBJECTIVES To explore the effects of cognitive stimulation therapy(CST)on patients with mild and moderate Alzheimer' s disease(AD),and to evaluate the effects of cognitive stimulation therapy on cognitive function,quality of life and activity of daily living of patients with mild and moderate Alzheimer's disease.The role of cognitive stimulation therapy is provide reference for exploring effective non-pharmacological interventions for patients with Alzheimer's disease.METHODS A total of 84 patients diagnosed as mild,moderate Alzheimer's disease and meeting the inclusion criteria were selected from a top three general hospital in Guangzhou.They were randomly divided into the CST group and the control group.Both groups received routine treatment and care.Among them,the CST group used cognitive stimulation therapy on the basis of the control group,and the frequency of intervention was 2 times a week for 7 weeks,30 to 45 minutes each time.Data of the mini-mental state examination(MMSE),Barthelh index(BI),Quality of Life-Alzheimer' s Disease(QOL-AD),and Montreal Cognitive Assessment(MOCA)of patients in two groups were collected at week 0,week 8 and week 11 and to evaluate the effects of cognitive stimulation therapy on cognitive function,quality of life and activities of daily living of patients with mild and moderate Alzheimer's disease.RESULTS (1)Comparison of MMSE scores: The scores of MMSE total score,orientation force score,recall skills score and language skills score in the CST group were higher than those in the control group at the 8th week and the 11 th week,and the difference was statistically significant(P<0.05).(2)Comparison of BI index scores: The scores of BI index in the CST group were higher than those in the control group at the 8th week and the 11 th week,but the difference was not statistically significant(P>0.05).(3)Comparison of QOL-AD scores: The QOL-AD scores in the CST group were higher than those in the control group at the 8th week and the 11 th week,and the difference was statistically significant(P<0.001).(4)Comparison of MOCA scores: The MOCA scores in the CST group were higher than those in the control group at the 8th week and the 11 th week,and the difference was statistically significant(P<0.001).(5)Comparison of scores of different scales: The MMSE score,QOL-AD score and MOCA score of patients in the CST group improved at 8th week and 11 th week than the pre-intervention(week 0),the difference was statistically significant(P<0.001),the MMSE score and BI index of the control group decreased at the 11 th week than the pre-intervention(week 0),and the difference was statistically significant(P<0.05).In the control group,the MOCA score was improved at the 8th week compared with the pre-intervention,and the difference was statistically significant(P<0.001).CONCLUSIONS (1)Cognitive stimulation therapy can improve the cognitive function of patients with mild to moderate Alzheimer's disease,especially in the dimensions of orientation,recall and language skills,and can also improve the quality of life of patients.(2)The effect of cognitive stimulation therapy on patients' memory,attention and computation,and activities of daily living remains to be further studied.(3)The effect of cognitive stimulation therapy on improving cognitive function and quality of life of patients with mild and moderate Alzheimer's disease can be maintained for at least one month after the termination of the intervention. |
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