Application Of CA125,CA199,CEA In The Diagnosis Of Benign And Malignant Pleural Effusion

Objectives To detect the expression levels and contents of CA125,CA199 and CEA in benign pleural effusion,malignant pleural effusion and serum,so as to further explore their clinical significance in the diagnosis of malignant pleural effusion and benign pleural effusion.Methods A total of 270 patients with pleural effusions(males : females,5 : 3;average age,64.47 ± 1.23 years)diagnosed in the Third Hospital of Qinhuangdao City from November 2015 to December 2018 were selected.The benign group included 120 patients with tuberculous pleural effusion,40 patients with inflammatory pleural effusion and 30 patients with exudative pleural effusion.The malignant group included 80 patients with malignant pleural effusion.Serum and pleural effusion were collected from the patients as subjects,and meanwhile serum was collected from 10 healthy individuals as control.The expression levels and contents of CA125,CA199 and CEA in serum and pleural effusion of the patients were detected using enzyme-linked immunosorbent assay(ELISA),and analyzed statistically.ROC curves were drawn to investigate the sensitivity,specificity and accuracy of CA125,CA199 and CEA.The difference between single detection and their combined detection was analyzed,so as to provide a theoretical basis for early clinical diagnosis of malignant pleural effusion and benign pleural effusion.Results 1.The expression levels and contents of serum CA125,CA199 and CEA in the malignant group were significantly higher than those in the benign group(P < 0.05).No statistical significance was found in the expression levels and contents of serum CA125,CA199 or CEA in the benign group,but they were significantly higher than those in the control group.2.The expressions and contents of CA125,CA199 and CEA in malignant pleural effusion were significantly higher than those in benign pleural effusion(P < 0.05).The expressions and contents of CA125,CA199 and CEA in pleural effusion showed no statistical significance in the benign group.3.The expressions and contents of CA125,CA199 and CEA in malignant pleural effusion were significantly higher than those in corresponding serum(P < 0.05).4.The expressions and contents of CA125,CA199 and CEA in tuberculous pleural effusion were significantly higher than those in corresponding serum(P < 0.05).With antituberculosis treatment,their levels decreased significantly.5.The sensitivity,specificity and accuracy of single detection of CA125,CA199 and CEA were significantly lower than those of their combined detection.Conclusions 1.The expressions and contents of CA125,CA199 and CEA in serum and pleural effusion play a role in differential diagnosis of benign and malignant effusion.2.The combined detection of CA125,CA199 and CEA is of greater significance than single detection in the differential diagnosis of malignant and benign pleural effusion.3.Serological detection provides some ideas for the diagnosis of pleural effusion in patients who cannot undergo thoracocentesis.Figure 3;Table 12;Reference 86...