Advances About The Study Of MicroRNAs In Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma(OSCC)is a kind of common and fatal malignant tumor,which tends to be confined to the head and neck.The destruction of adjacent tissues and the characteristic of neck lymphatic metastasis caused serious physical and psychological harm to the patients.MicroRNAs(miRNAs),as the noncoding short RNA molecules without function of protein-coding,are usually encoded by endogenous genes,and exert suppressive effect on post-transcriptional regulation of respective target genes by translation repression or degradation of mRNA,which subsequently mediate activation or blocking of downstream signal pathways associated with oral squamous cell cancer.Aberrant expressive level of certain miRNAs has been confirmed in cell experiments,clinical carcinomatous specimens,saliva,serum or plasma,it is connected with multiple aspects of oral squamous cell cancer including tumorous growth,cellular proliferation,apoptosis,migration,invasion,metastasis,glycometabolism,radiosensitivity or chemosensitivity and signal pathways associated with oral squamous cell cancer.These miRNAs are seized of the potential in clinical application as a kind of minimally invasive ornon-invasive method applied in early diagnosis and prognosis by detection of serum,plasma and saliva,and may provides a new ancillary or additional reference index of traditional pathological grading and clinical staging,or an prognostic biomarker,even the more effective therapy to oral squamous cell cancer,promisingly.