| Objective: To investigate value of G test and GM test for IFD was discussed through the results of blood fungal culture.Methods:A retrospective analysis was performed on the results of inpatients with G test,GM test,and fungal blood culture conducted at the First Affiliated Hospital of Chongqing Medical University from March2017 to June 2018.A total of 455 suspected suspected IFDs were collected.Using postive blood culture fungal as gold standard to confirm IFD,the cases were divided into IFD group and non-IFD group,IFD group: 49 cases;non-IFD group:406 cases;The G and GM tests were used to diagnose the invasive fungal infections of Sen,Spe,PPV,NPV,and the equivalent energy index.Results:The IFD group’s G test values were: 243.7±268.3 pg/mL and GM test serological index were 0.47±0.70;non-IFD group G tests and GM test serological index were respectively 23.1±52.3pg/mL and 0.25±0.24,the difference between the two groups was statistically significant(P<0.001).The sensitivity,specificity,positive predictive value,negativepredictive value,coincidence rate,and Youden index of the G test and GM test for IFD diagnosis were 65.3%,95.3%,62.7%,95.7%,92.1%,0.606,and 24.5%,respectively 93.6%,31.6%,91.1%,86.2%,0.181;The specificity of the combined diagnosis of IFD was 99.0%.Conclusion: The clinical application value of G test and GM test was studied by using the results of blood culture fungi as the "gold standard" for the diagnosis of IFD,which reduced the uncertainty caused by the clinical diagnosis of IFD.This study showed that G test showed better diagnostic value for the diagnosis of IFD,and combined with GM test could improve the sensitivity and accuracy of the diagnosis of IFD.In addition,negative test results can not be ignored in excluding diagnosis IFD.Reasonable application and comprehensive analysis of the two tests can improve the diagnosis and treatment level of IFD,promote early diagnosis,and further reduce the rate of misdiagnosis and missed diagnosis. |
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