Analysis Of Risk Factors Associated With Atherosclerosis In Patients With Hypothyroidism

Objective:To explore the risk factors of atherosclerosis caused by hypothyroidism.Methods:152 patients with hypothyroidism who met the criteria were selected,including 101 patients with subclinical hypothyroidism and 51 patients with clinical hypothyroidism.Subjects were included for age,sex,body mass index(BMI),thyroid stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4),TC,TG,LDL-C,and HDL-C.Carotid intima-media thickness(cIMT)was measured by cervical vascular ultrasound.According carotid intima-media thickness(cIMT)values were divided into three groups.They were 32 cases of normal carotid artery group(group A),27 cases of IMT thickening group(group B)and 93 cases of plaque formation group(group C),of which group B and group C can be collectively referred to as atherosclerosis(AS)group.Then logistic regression was used to analyze the risk factors of atherosclerosis in patients with hypothyroidism.At the same time,101 patients with subclinical hypothyroidism were subjected to TSH stratification,and then logistic regression was used to analyze the risk factors of atherosclerosis and the risk factors of plaque severity in patients with subclinical hypothyroidism.Results:1.The age,TSH and LDL-C levels in the AS group were significantly higher than those in the A group.The HDL-C level was significantly lower than that in the A group(P<0.01).2.Logistic regression analysis was performed using factors such as TSH,age,LDL-C,and HDL-C as independent variables in patients with hypothyroidism who had atherosclerosis as a dependent variable.The results showed that TSH,age and LDL-C were risk factors for atherosclerosis in patients with hypothyroidism(P<0.05,P<0.01).3.Logistic regression analysis was performed using TSH,age,LDL-C,and HDL-C as independentvariables in patients with subclinical hypothyroidism who had atherosclerosis as a dependent variable.The results showed that TSH,age and LDL-C were risk factors for atherosclerosis in SCH patients(P<0.05),and TSH had a significant effect on them(OR=17.621).It is suggested that for each additional level of TSH,the risk of AS increases by 16.621 times.4.Logistic regression analysis was performed using the different severity of atherosclerosis(light and severe AS)as a dependent variable in subclinical hypothyroidism patients with TSH,age,LDL-C,HDL-C and other factors as independent variables.The results showed that TSH and age were risk factors for different severity of atherosclerosis in SCH patients(P<0.05),and suggested that for each additional level of TSH,the severity of AS plaque increased by 5.736 times(OR=6.768).Conclusion:1.In patients with subclinical hypothyroidism,the risk of atherosclerosis and the severity of plaque are significantly associated with elevated levels of TSH.Therefore,clinically,such patients are highly valued and treated in time to delay and reduce the occurrence of atherosclerosis.2.Risk factors for atherosclerosis in patients with hypothyroidism include TSH,age,and LDL-C.