Preliminary Study On The Relationship Between TCM Syndrome Types And Laboratory Indicators Of Rheumatoid Arthritis

Objective:Exploring whether there is a relationship between TCM syndromes of patients with rheumatoid arthritis and clinical objective laboratory indicators,than the TCM syndrome differentiation can contacted to clinical objective laboratory indicators,and make TCM syndrome differentiation and treatment combined with modern testing methods,provide ideas for the quantitative study of TCM syndrome differentiation of rheumatoid arthritis and to seek better treatment options.Method:This study used a retrospective research method to design a questionnaire and then searched the medical record system for the first diagnosis of rheumatoid arthritis patients in the Department of Rheumatology,Shenzhen Traditional Chinese Medicine Hospital from January 2015 to March 2018.Data,the main data of the patient’s gender,age,and course of disease,the four medicines of Chinese medicine in first day admission,and the laboratory test data of the second day of admission,and the rheumatoid arthritis disease issued by the Chinese Medicine Association of China in 2017.According to the"Guidelines for the Combination of Diagnosis and Treatment of Rheumatoid Arthritis" issued by the Chinese Medicine Association of China in 2017,the dialectical of TCM was obtained and the results of TCM classification were obtained.Statistical analysis was used to analyze the relationship between TCM syndrome types and laboratory test indicators.Result:1.A total of 408 patient records were selected in this study,72 males(17.65%)and 336 females(82.35%).The prevalence of females was higher than that of males,and the ratio was about 4.67:1.Among the 408 cases,the youngest was 21 years old and the oldest was 84 years old,with an average of 54.28±14.19 years old;the shortest course was 1 year,the longest was 50 years,and the average was 9.66±8.17 years.2.Distribution of syndrome type:71 cases(17.4%)with wind and dampness resistance syndrome,34 cases(8.3%)with cold and dampness resistance syndrome,76 cases(18.6%)with dampness and heat stasis syndrome,72 cases(17.6%)with phlegm and stasis resistance syndrome,and there were 33 cases(8.1%)with blood stasis syndrome,32 cases(7.8%)with qi-blood deficiency syndrome,30 cases(7.4%)with qi-blood deficiency syndrome,60 cases(14.7%)with liver-kidney deficiency syndrome3.Types of syndromes and related situations:①There is no difference in gender distribution among the syndrome types(P>0.05).②There was a clear difference in age distribution among each syndrome type(P<0.01).Compared with wind and dampness resistance syndrome,the age of phlegm and stasis resistance syndrome,qi-blood deficiency syndrome,Qi-Yin deficiency syndrome and liver-kidney deficiency syndrome were apparently increased(P<0.05).③The course of disease was significantly different in the distribution of each syndrome type(P<0.01).Compared with wind and dampness resistance syndrome,the course of phlegm and stasis resistance syndrome,blood stasis syndrome,qi-blood deficiency syndrome,Qi-Yin deficiency syndrome and liver-kidney deficiency syndrome were apparently increased(P<0.01).4.Syndrome and laboratory indicators:①There was no difference between the syndrome types of RF level(P>0.05).②There were a clear differences between the ESR levels(P<0.01).Compared with the blood stasis syndrome,the ESR levels of wind and dampness resistance syndrome,cold and dampness resistance syndrome,dampness and heat stasis syndrome,phlegm and stasis resistance syndrome,Qi-Yin deficiency syndrome and liver-kidney deficiency syndrome were significantly increased(P<0.05);compared with the qi-blood deficiency syndrome,the ESR levels of wind and dampness resistance syndrome,cold and dampness resistance syndrome,dampness and heat stasis syndrome,phlegm and stasis resistance syndrome,Qi-Yin deficiency syndrome and liver-kidney deficiency syndrome were significantly increased(P<0.05).③There were a clear differences between the CRP levels(P<0.01).Compared with the qi-blood deficiency syndrome,the CRP levels of dampness and heat stasis syndrome,phlegm and stasis resistance syndrome were significantly increased(P<0.05).④There was no difference between the syndrome types of TG level(P>0.05).⑤There were a clear differences between the TC、HDL-C、LDL-C levels(P<0.01).Compared with wind and dampness resistance syndrome,the TC levels of the qi-blood deficiency syndrome,Qi-Yin deficiency syndrome were clear increased(P<0.05);compared with phlegm and stasis resistance syndrome,the TC levels of the qi-blood deficiency syndrome,Qi-Yin deficiency syndrome were clearly increased(P<0.05).Compared with the qi-blood deficiency syndrome,the HDL-C levels of wind and dampness resistance syndrome,cold and dampness resistance syndrome,dampness and heat stasis syndrome,phlegm and stasis resistance syndrome,blood stasis syndrome and liver-kidney deficiency syndrome were clearly increased(P<0.05);compared with the,Qi-Yin deficiency syndrome,the HDL-C levels of wind and dampness resistance syndrome,cold and dampness resistance syndrome,dampness and heat stasis syndrome,phlegm and stasis resistance syndrome,blood stasis syndrome ’and liver-kidney deficiency syndrome were clearly increased(P<0.05).Compared with the wind and dampness resistance syndrome,the LDL-C levels of Qi-Yin deficiency syndrome were clearly increased(P<0.05).Conclusion:1,Dampness and heat resistance syndrome,phlegm and stasis resistance syndrome,wind and dampness resistance syndrome and liver-kidney deficiency are more common types of RA.Patients with liver-kidney deficiency syndrome,qi-blood deficiency syndrome,Qi-Yin deficiency syndrome and phlegm and stasis resistance syndrome have a larger average age and a longer course.2,There was no significant difference in RF levels among RA syndromes.3,ESR,CRP levels was significantly reduced in qi-blood deficiency syndrome,significantly increased in dampness and heat resistance syndrome and phlegm and stasis resistance syndrome.4.The level of TC and HDL-C was distinctly increased in qi-blood deficiency syndrome and Qi-Yin deficiency syndrome.The level of TC was significantly reduced in wind and dampness resistance syndrome and phlegm and stasis resistance syndrome.The level of LDL-C was significantly increased in Qi-Yin deficiency syndrome and reduced in wind and dampness resistance syndrome.