Clinical Analysis Of Factors Affecting Prognosis Of Hepatitis B-associated Hepatocellular Carcinoma With Abnormal Glucose And Lipid Metabolism

Purpose: To study the effect of metabolic risk factors on the survival and prognosis of HBV-associated hepatocellular carcinoma patients.Methods:404 patients of hepatocellular carcinoma with HBV admitted to the first affiliated hospital of Xinjiang Medical University from May 2000 to November 2016.Obesity,hyperglycemi,hypertriglyceridemia,hypercholesterolemia and hypertension as baseline data were assigned to different metabolic risk categories.According to the level of hepatitis B DNA load,the cases were groupedand Kaplan-Meier curves were plotted.Interlayer stratificationdifferences are determined by using Wilcoxon test to understand the effects of metabolic risk factors on the prognosis of hepatocellulthe carcinoma.Results: Different metabolic risk factors have significant differences in the survival and prognosis of hepatocellular carcinoma.In the low hepatitis B DNA load group(<10000 copies/ml),there was no statistical difference in the effect of metabolic risk factors on the prognosis of hepatocellular carcinoma(P=0.234);In the high hepatitis B DNA load group(≥ 10000 copy/ml),the mortality risk of HBV-associated hepatocellular carcinoma with obesity and/or hyperglycemia were significantly increased(P=0.019).In addition,the risk of death raised with the increase of metabolic factors(P=0.007).Conclusion: Metabolic factors increase the risk of death in HBV-associated hepatocellular carcinoma patients in the group of high HBV DNA load.