The Correlation Between Plasma Concentration And Adverse Reactions,efficacy In Patients With Gynecologic Tumor After Paclitaxel Liposome-based Chemotherapy

Objective:To analyze the correlation between plasma concentration and adverse reactions,efficacy in 76 patients with gynecologic tumor after paclitaxel liposome-based chemotherapy.Methods:The blood concentration of paclitaxel liposome after chemotherapy was detected by nano-enhanced immunoturbidimetry using a fully automated analyzer.Subsequently,the plasma concentrations of 76 gynecologic tumor patients who received paclitaxel liposome-based chemotherapy were explored.The patients were grouped according to the mean Tc>0.05 values,which were Tc>0.05 value<38h group and Tc>0.05 value>38h group.Chi-square test was used to analyze the differences of basic data,adverse reactions,treatment outcome,progression free survival time(PFS)and overall survival time(OS)between the two groups.Result:Accuracy of MyCare paclitaxel drug blood concentration monitoring kit:relative deviation(B)≤±15%,precision:(1)repeatability:coefficient of variation(CV)≤5%(2)batch-to-batch difference:relative deviation(R)≤ 10%,in line with the determination of paclitaxel liposome blood concentration.The results showed that there were no significant differences in age,tumor type,nausea and vomiting,fatigue and constipation status between the group of Tc>0.05 value<38h and the group of Tc>0.05 value≥38h(P>0.05).However,there were significant differences in leukopenia,neutrophil reduction,hemoglobin reduction and platelet reduction between the two groups(P<0.05).The results also showed a significant difference in the efficacy of chemotherapy between the two groups(χ2=8.815,P=0.0319).However,there were no significant differences in the progression free survival time and overall survival time between the two groups(P=0.931 and P=0.8411).Conclusion:The MyCare paclitaxel drug blood concentration monitoring kit is stable and reliable for the determination of paclitaxel liposome content in the blood.The plasma concentration of paclitaxel liposome has a certain correlation with adverse reactions and clinical efficacy,which may provide some references for clinical tumor chemotherapy.