The Changes Of Serum Anterior Gradient Protein-2 Level After Radical Cystectomy And Its Clinical Significance

Objective:To investigate the changes of serum anterior gradient protein-2(AGR-2)level after radical cystectomy and its clinical significance.Methods:A total of 80 cases of bladder cancer patients in our hospital from March 2013 to May 2018 were selected as research subjects,while 30 healthy volunteers were selected as the control group.All of the bladder cancer patients underwent laparoscopic radical cystectomy.The serum AGR-2 level before and after operation was detected by Elisa.The effects of serum AGR-2 on patients’ overall survival(OS)and progression free survival(PFS)were analyzed,and the prognostic factors were analyzed by Cox proportional risk regression model.Results:80 patients successfully completed the laparoscopic radical cystectomy,no transfer to open surgery,no death.The serum AGR-2 in bladder cancer patients was significantly higher than that of the control group[(33.5±9.4)vs(8.5±2.1)ng/ml,P<0.05],4 weeks after the operation,the serum AGR-2 was significantly lower than that before the operation[(17.8±4.1)vs(33.5±9.4)ng/ml,P<0.05].4 weeks after the operation,PFS(23 vs 15 months,P<0.05)and OS(36 vs 23 months,P<0.05)were significantly higher in patients with low level of serum AGR-2.Cox proportional hazards regression analysis showed that postoperative serum AGR-2,tumor staging and lymph node metastasis were independent risk factors for prognosis(P<0.05).Conclusion:AGR-2 level is significantly reduced after radical cystectomy.AGR-2 has certain significance to judge the curative effect of operation.Postoperative AGR-2 level is helpful to the prognosis of patients.