Clinical Study On Xiaozheng Sanji Prescription Ⅰ In The Treatment Of Non-alcoholic Fatty Liver Disease Of Damp Depression And Stasis Typeabstract

To observe the changes of clinical symptoms and indicators in patients with non-alcoholic fatty liver disease(NAFLD)of dampness stagnation and blood stasis type treated by Xiaozheng Sanji Prescription Ⅰ,and to evaluate the clinical efficacy of Xiaozheng Sanji Prescription Ⅰ in treating NAFLD of dampness stagnation and blood stasis type.Sixty NAFLD patients who met the inclusion criteria were randomly divided into treatment group(30 cases)and control group(30 cases).Two groups of patients were given healthy lifestyle guidance.The treatment group was given Xiaozheng Sanji Prescription Ⅰ orally,while the control group was given Silybin Capsule orally.Both groups took medicine for 12 weeks continuously.At the end of the course of treatment,the changes of TCM symptoms,total curative effect of syndromes,blood lipid,liver function,body weight and waist circumference were observed before and after treatment.The results showed that the symptoms of hypochondriac pain,dull complexion,abdominal distension,body weight sleepiness,nausea and vomiting,and sticky mouth in the treatment group were significantly improved(P < 0.05);the symptoms of dry mouth,dark face and hypochondriac pain in the control group were significantly improved(P < 0.05);the symptoms of hypochondriac rib pain,dim complexion,abdominal distension,heavy somnolence and fatigue in the treatment group were significantly improved(P < 0.05).The improvement of nausea,vomiting and stickiness in the mouth was better than that in the control group(P < 0.05).The total curative effect of TCM syndromes: the total effective rate of treatment group was 83.3%,and that of control group was 63.3%.The total effective rate of treatment group was better than that of control group,with statistical significance(P=0.035,P<0.05).Blood lipid level: LDL,TG and TC in the treatment group improved significantly with statistical difference(P < 0.05);TC and LDL in the control group improved with statistical difference(P < 0.05);LDL and TG in the treatment group improved better than that in the control group,with statistical difference(P < 0.05).Liver function: ALT,AST and GGT in the treatment group were improved with statistical difference(P < 0.05);ALT,AST and GGT in the control group were improved with statistical difference(P < 0.05);ALT,AST and GGT in the treatment group were improved with no statistical difference compared with the control group(P > 0.05).Weight: The weight of the treatment group and the control group were reduced,with statistical difference(P < 0.05);compared with the control group,the weight of the treatment group was significantly reduced,with statistical significance(P = 0.027,P < 0.05).Waist circumference: The waist circumference of the treatment group was significantly reduced(P=0.026,P<0.05);the waist circumference of the control group was not significantly reduced(P=0.101,P>0.05);compared with the control group,the waist circumference of the treatment group was significantly reduced(P=0.039,P<0.05).Safety: There were no adverse events in the treatment group and control group.In conclusion,Xiaozheng SanJi Prescription Ⅰ is effective in treating NAFLD of dampness stagnation and blood stasis type.Improve clinical symptoms and blood lipids,reduce weight,reduce waist circumference.