Correlation Between Thromboembolic Risk Score And Blood Pressure Level In Patients With Non-valvular Atrial Fibrillation

Objective : To explore the correlation between the risk score of thromboembolism and blood pressure grade in patients with non-valvular atrial fibrillation,and to provide reference for further improving the current clinical thromboembolic risk assessment model(CHADS2 score and CHA2DS2-VASc score).Methods:A total of 511 patients in the Central Hospital of Shaoyang with non-valvular atrial fibrillation were enrolled,from August 2016 to October 2018.The clinical information of these patients with non-valvular atrial fibrillation was collected,including age,gender,blood pressure rating,and comorbidities(eg,diabetes,heart failure,myocardial infarction,aortic plaque,peripheral arterial disease,the history of stroke/transient ischemic attack/thromboembolic).Then according to different blood pressure levels,patients with non-valvular atrial fibrillation were divided into four groups:group A(non-hypertensive group),group B(mild hypertensive group);group C(moderate hypertensive group);group D(severely hypertensive group),all cases were scored using the CHADS2 score table and the CHA2DS2-VASc score table;the correlation between CHADS2 score,CHA2DS2-VASc score and blood pressure level was analyzed.Statistical analysis was performed using the SPSS 22.0 software package,and the corresponding statistical methods were used for analysis based on the characteristics of the data.P <0.05 was considered to be statistically significant.Results:(1)There were no significant differences in gender,age,and congestive heart failure between the four groups(P >0.05).There were significant differences in diabetes,the history of stroke/transient ischemic attack/thromboembolism,and vascular disease between the four groups of patients(P <0.05).The proportion of diabetes,the history of stroke/transient ischemic attack/thromboembolism and vascular disease in mild,moderate,and severe hypertension group was higher than that in non-hypertension group(P <0.05).The proportion of diabetes,the history of stroke/transient ischemic attack/thromboembolism and vascular disease in mild,moderate,and severe hypertension group was match(P >0.05).(2)CHADS2 score,CHA2DS2-VASc score of the four groups were different(P <0.05);and the pairwise comparison was statistically significant(P <0.05).(3)The four groups of CHADS2 score,CHA2DS2-VASc score increased with the increase of blood pressure level(r=0.480,P <0.001,r=0.436,P <0.001).The four groups ofCHADS2 score,CHA2DS2-VASc score increased with the increase of level of hypertension(r=0.142,P <0.05,r=0.198,P <0.001).Conclusions : The CHADS2 score,CHA2DS2-VASc score of patients with non-valvular atrial fibrillation were positively correlated with blood pressure levels,so the CHADS2 score,CHA2DS2-VASc score should be improved in combination with blood pressure levels to more accurately predict the risk of thromboembolism in patients with non-valvular atrial fibrillation.