| BackgroundCompared with the general population,the average life expectancy of schizophrenics is reduced by 20%.Most of the patients die from cardiovascular diseases and obesity-related diseases.There are many factors influencing the occurrence of cardiovascular metabolic disorders in schizophrenics,such as unhealthy diet and living habits,genetic factors,Antipsychotic medication is also one of the important factors.At present,the early metabolic risk of disease and antipsychotic drugs in the effect of early treatment on metabolic haven’t get consistent reports,most studies use chronic patients as the research object,and these patients had longer duration,there are a lot of confounding factors,in addition,the patients before treatment of antipsychotic drug use is unknown,so we can not explain the relationship between disease and metabolic risk clearly.Therefore,in order to solve the clinical course of patients and the influence of antipsychotic drug treatment,we use the FES(First-episode schizophrenia,FES)as the research object to study the early metabolic characteristics of adolescent schizophrenia patients and the early metabolic characteristics of patients treated with antipsychotic drugs.ObjectiveTo study the early metabolic characteristics of adolescent schizophrenia patients and the early metabolic characteristics of patients treated with antipsychotic drugsMethodsThe study population was schizophrenic patients in henan mental health center.The hospitalized patients from 2008 to 2015,aged 14-24 years old,with a two-year duration of illness and had not used antipsychotic drugs before admission.Extract social demographic information,disease-related information,medication information,and various metabolic indicators before and after exposure to antipsychotic drugs.This research adopts the 2006-2011 the National Physique and the Health Database(National Physique and the Health Database,NPHD)by contrast,Descriptive statistical analysis was used to describe the changes of metabolic indexes in the early stage of the disease and the early stage of drug therapy,to assess the effect of antipsychotic on metabolic index,using the chi-square test and paired t test for comparing on admission and after treatment levels.Spss21.0 was used for statistical analysis,and p<0.05 was considered statistically significant.ResultsThere were 503 first-episode schizophrenia(FES)inpatients who met the inclusion criteria.1.At baseline,the abnormal rate of low HDL-C(HDL-C)in patients with schizophrenia was significantly higher than that in the national control group(15.4%vs 4.8%,p<0.001),and the pre-diabetes incidence was significantly lower than that in the national control group(6.9%vs 11%,p=0.007),albumin levels were significantly lower than in the national control group(43.5±3.5 vs 49.5±3.4,p<0.001).2.After a short-term antipsychotic treatment,the risk of lipid metabolism is significantly increased.Compared with baseline,patients had significantly elevated triglyceride levels(1.43±0.71 vs 0.94 ±0.44,p<0.001),high triglyceride abnormality rate(26.5%vs 6.2%,p<0.001),and low HDL-C rate was elevated(27.3%vs 15.4%,p<0.001),while D3-hydroxybutyrate levels were significantly reduced.Low HDL-C rates(28.1%vs 15.5%,p=0.002)increased in women when grouped by gender,but not in men.After drug treatment,fasting blood glucose and glycated serum protein levels were significantly lower in patients with schizophrenia,serum albumin levels were significantly lower(42.1±3.7 vs 43.7 ± 3.4,p<0.001),and creatinine and urea nitrogen levels were also significantly reduced.Conclusion1.At baseline,low albumin and HDL-C are prominent metabolic risk characteristics of FES patients.2.After drug exposure,Triglycerides is significantly increased,and D3-hydroxybutyric acid and serum albumin levels are significantly decreased. |
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