Clinical Significance Of Serum Gastrin-17,C-reactive Protein And D-dimer In Henoch-Schonlein Purpura Children With Abdominal Symptoms

Objective To investigate the clinical significance of serum gastrin-17(G-17),C-reactive protein(CRP)and D-dimer(D-D)levels in early diagnosis and severity of Henoch-Scholein purpura(HSP)children with abdominal symptoms.Methods Analyse the clinical data of 120 children with initial HSP admitted to the Department of Pediatrics,the First Affiliated Hospital of Anhui Medical University from December2016 to December 2017.Serum gastrin-17 and C-reactive protein levels in acute phase in HSP children with abdominal symptoms were detected by Enzyme-linked immunosorbent assay(ELISA),serum D-dimer levels in acute phase in HSP children with abdominal symptoms were detected by Immunoturbidimetry,especially in HSP children with early gastrointestinal symptoms,and the correlation between these parameters and purpura symptom scores was analyzed.Combining with results of gastroscope,the severity of HSP with abdominal symptoms was evaluated.Results(1)Serum gastrin-17 level(pmol/L)in HSP children with abdominal symptoms were obviously lower than that in nomal control group(3.12±1.64 vs 7.15±1.03),and the difference was statistically significant(P<0.001);serum gastrin-17 level in HSP children with abdominal symptoms were obviously lower than that in other type HSP group(3.12±1.64 vs 6.85±1.28),and the difference was statistically significant(P<0.001);the decrease of serum gastrin G-17 level in abdominal HSP children with early gastrointestinal symptoms was more significant(1.77±0.50 vs 4.01±1.51),the difference was statistically significant(P<0.001).(2)Serum C-reactive protein level(mg/L)in HSP children with abdominal symptomswere obviously higher than that in normal control group(18.39±4.48 vs 3.95±1.65),and the difference was statistically significant(P<0.001),which was increased most significantly in abdominal HSP children with early gastrointestinal symptoms(19.98±5.45 vs 17.33±3.37),and the difference was statistically significant(P<0.05).(3)Serum D-dimer protein level(mg/L)in HSP children with abdominal symptoms were obviously higher than that in normal control group(2.53±1.17 vs 0.59±0.41),and the difference was statistically significant(P<0.001),which was increased most significantly in abdominal HSP children with early gastrointestinal symptoms(3.48±0.96 vs 1.89±0.80),and the difference was statistically significant(P<0.001).(4)Serum gastrin-17 levels were negatively correlated with purpura symptom scores(r=-0.8701,P<0.01);serum C-reactive protein and D-dimer levels were both positively correlated with purpura symptom scores(r=0.9277,0.8340,all P<0.01).(5)The pathological changes under gastroscope were the most obvious in abdominal HSP children with early gastrointestinal symptoms(c2=8.0952,P<0.05).Conclusion Combined determination of serum gastrin-17,C-reactive protein and D-dimer levels in acute phase can be used as serological markers for early diagnosis of HSP children with abdominal symptoms(especially in HSP children with early gastrointestinal symptoms).