Effects Of Fatty Liver On Serum Testosterone Levels In Elderly Men

Objectives The effect of changes in serum testosterone levels on metabolism in elderly men has been a focus of research in recent years.Our previous clinical study found that the serum testosterone levels of elderly men decreased with the increase of age,and the change of testosterone levels affected the glucose and lipid metabolism,which was also correlated with atherosclerosis and metabolic syndrome.Further basic research on middle-aged castrated SD rats supplemented with different testosterone concentration gradients showed that serum testosterone concentration increased glucose and lipid metabolism disorder,atherosclerosis process was improved,and liver fat infiltration was reduced.Based on the above results,the study investigated the effect of fatty liver on serum testosterone levels in elderly men through clinical observation.Methods Retrospective analysis was conducted on the clinical data of 130 cases of elderly man aged 45-90,average age(69.91±17.90),who visited one hospital from January 2015 to January 2018 were analyzed retrospectively to collect clinical data of patients,and relevant clinical data were collected,Including: general data: age,body height,weight,and calculation of body mass index(BMI),history of disease,medication;Blood test biochemical data serum triglycerides(TG),total cholesterol(TC),LDL-C,HDL-C,fasting blood sugar(FBG),fasting insulin(FINS),testosterone(T),estrogen(E),and calculate insulin resistance index(HOMA-IR)and estrogen/testosterone(E/T);Imaging data detailed report of abdominal color Doppler ultrasound.Results 1.BMI,FBG,FINS and HOMA-IR of elderly man with fatty liver group were significantly higher than those in the non-fatty liver group(P < 0.05).TC and TG in the fatty liver group were higher than those in the non-fatty liver group,and the difference was statistically significant(P < 0.05).There was no statistical difference in LDL-C and HDL-C between the two groups(P > 0.05).The relative number of LDL-C in the fatty liver group was higher than that in the non-fatty liver group,and the relative number of HDL-C was lower than that in the non-fatty liver group,indicating a clinical trend.2.Alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in the fatty liver group were higher than those in the non-fatty liver group,and the difference was statistically significant(P < 0.05).Fatty liver testosterone levels lower than the non-fatty liver group,the difference was statistically significant(P < 0.05),estrogen/testosterone is higher than in non-fatty liver group,the difference was statistically significant(P < 0.05),two groups of estrogen level no statistical difference(P > 0.05),higher than in non-fatty liver group,the relative abundance of fatty liver group of estrogen have clinical trend.3.There was a negative correlation between testosterone and TG,FBG,FINS,and HOMA-IR(r < 0),with statistical difference(P < 0.05).There was a negative correlation between testosterone and BMI,TC,and LDL-C(r < 0),with no statistical difference(P > 0.05),and a positive correlation between testosterone and HDL-C(r > 0),with no statistical difference(P > 0.05).Conclusion 1.The testosterone level of the elderly male fatty liver group was lower than that of the non-fatty liver group.2.The normal liver function of elderly male with fatty liver may have been caused by the disorder of the internal environment of sex hormones,the decrease of serum testosterone level,the increase of estrogen level and the imbalance of the ratio of estrogen to testosterone.3.Changes in testosterone levels in elderly men are related to the metabolic components.Correcting the disorder of internal environment of sex hormones in elderly men may be beneficial for improving the disorder of glucose and lipid metabolism,the condition of fatty liver and the long-term quality of life.