Influencing Factors Of Early Recurrence In Patients With Primary Hepatocellular Carcinoma After Surgical Resection

ObjectiveTo study the influencing factors of early recurrence of hepatocellular carcinoma(HCC)after surgical resection,so as to guide clinical treatment.MethodsThe clinical data of 450 patients with primary hepatocellular carcinoma after surgical resection from January 1,2014 to December 31,2015 in Hepatobiliary Surgery Department of the First Affiliated Hospital of Zhengzhou University were retrospectively analyzed.SPSS 21.0 professional statistical software was used to analyze the data and Cox proportional risk regression was used to analyze the risk factors of early recurrence of hepatocellular carcinoma.ResultsA total of 182 cases(40.4%)of hepatocellular carcinoma recurred,including 53 cases(29.1%)within 6 months after operation,62 cases(34.1%)within 6 months to 1 year after operation,and 67 cases(36.8%)within 1 to 2 years after operation.The early recurrence of hepatocellular carcinoma patients after operation was related to the number of tumors,the maximum diameter of tumors,the degree of differentiation of tumors,portal vein tumor thrombus and serum AFP level(P < 0.05),but not to age,sex,Child-Pugh grade,hepatic portal blocking time,HBV/HCV infection,intraoperative blood loss and blood transfusion(P > 0.05).Cox proportional-risk regression analysis showed that the number of tumors(RR = 2.148,95.0% CI 1.175-3.924,P = 0.013),the maximum diameter of tumors(RR = 1.591,95.0% CI 1.006-2.518,P = 0.047),tumor differentiation(RR = 1.463,95.0% CI 1.071-1.998,P = 0.017),portal venous thrombosis(RR = 1.835,95.0% CI 1.141-2.601,P=0.010)are all risk factors for early recurrence of hepatocellular carcinoma after operation.ConclusionsNumber,maximum diameter,degree of differentiation of tumors,portal vein thrombus and serum AFP levels are all independent risk factors for early recurrence of patients with primary liver cancer after surgical resection.Assessment of these factors has certain guiding significance in preventing early recurrence,early detection and early treatment.