Clinical Efficacy And Mechanism Of Antioxidation By Xiaoshuan Enteric-coated Capsule In The Treatment Of Carotid Atherosclerosis With Qi Deficiency And Blood Stasis

Objective:To observe the effects of Xiaoshuan enteric-coated capsules on plasma levels of ox-LDL,SOD,MDA and carotid intima-media thickness(IMT),acoustic(AD)density in patients with atherosclerosis in qi deficiency and blood stasis.To explore the mechanism of antioxidation by xiaoshuan enteric-coated capsule in the treatment of carotid atherosclero-sis.Methods:60 patients who meet the certain conditions of inclusion were randomly divided into the control group(30 cases)and the treatment group(30 cases)after obtaining their consent.They all collected from the hospital of Shanxi College of Traditional Chinese Medicine between 2016.12 to 2017.6.Patients in the control group were given aspirin 100 mg once daily and simvastatin tablets 20 mg once daily.On the basis of the treatment group,two capsules of Xiaoshuan enteric-coated capsules were added to the treatment group three times daily.The course of treatment was 3 months.The changes of TCM symptoms before and after treatment were observed.The levels of ox-LDL,SOD,MDA and carotid artery IMT were measured before and after treatment.Statistical data were analyzed by using statistical software spss23.0.Before and after treatment,After treatment between the various changes,a clear statistical significance.Results:Comparison within the group:After treatment,the levels of ox-LDL and MDA decreased and the activity of SOD increased in the treatment group and the control group(P<0.05);the IMT value of the carotid artery decreased(P<0.05);Improvement(P<0.05);Acoustic density of lipid plaques increased(P<0.05);TCM symptom scores all decreased(P<0.05).Comparison between groups:(1)After treatment,the ox-LDL and MDA levels in the treatment group were significantly lower than those in the control group,and the SOD value was significantly increased(P<0.05).(2)After treatment,the treatment group had more carotid IMT than the control group.The level of decline was comparable and there was no statistically significant difference(P>0.05).(3)After treatment,the acoustic density of the lipid plaque in the treatment group was significantly lower than that in the control group(P<0.05).(4)After treatment,treatment Compared with the control group,the scores of TCM symptoms decreased significantly and the total effective rate was higher.The difference was statistically significant(P<0.05).(5)After treatment,the treatment grouphad less fatigue,shortness of breath,spontaneous perspiration,numbness in limbs than the control group.Pain,venous stasis,and skin tropism were significantly improved.The differences were statistically significant(P<0.05),and the improvement of amnesia symptoms was comparable,with no statistically significant difference(P>0.05);(6)Safety observations were not seen.Obviously abnormal.Conclusion: The ox-LDL levels in the treatment group of Xiaosuan enteric-coated capsules decreased,the acoustic densities of the lipid plaques improved,and the symptoms of the patients improved effectively,indicating that the drug interferes with the occurrence and development of atherosclerosis by reducing lipid peroxidation.The method of tonifying qi and activating blood can significantly improve the symptoms of patients with qi deficiency and blood stasis type atherosclerosis,and provide a theoretical basis for Chinese medicine to effectively prevent and improve atherosclerotic diseases.