Expression And Significance Of PD-1 On CD4+and CD8+T Cells In Tumor Tissues And Adjacent Tissues Of NCSLC

Objective To explore the expression and significance of programmed death-1(PD-1)on CD4+and CD8+T cells in tumor tissues and adjacent tissues of patients with non-small cell lung cancer(NCSLC).Methods The expressions of PD-1 on CD4+and CD8+T cells in the tumor tissues of79 NSCLC patients and the adjacent tissues of 78 NSCLC patients were detected by flow cytometry analysis,and the correlations between PD-1 expressions and clinicopathological characteristics of NSCLC patients were analyzed.Results Compared with adjacent tissues,the expression level of PD-1+cells in all cells of tumor tissues was significantly higher with the difference statistically significant(P<0.01).The expression level of CD4+and CD8+T cells in tumor tissues was significantly higher with the difference statistically significant(P < 0.01).The expression level of PD-1 on CD4+and CD8+T cells in tumor tissues was significantly higher with the difference statistically significant(P < 0.01).The expressions of PD-1 on CD4+and CD8+T cells in patients with tumor diameter>3cm were higher than those with tumor diameter≤3cm,the difference was statistically significant(P<0.05).The expressions of PD-1 on CD8+T cells in patients with lung squamous cell carcinoma were higher than those with lung adenocarcinoma,and the difference was statistically significant(P <0.05),while the expressions of PD-1 on CD4+T cells were not statistically significant(P>0.05).The expressions of PD-1 were not related to the gender,age,pathologic stages and lymph node metastasis(P>0.05).Conclusion The expression level of PD-1 on CD4+and CD8+T cells in tumor tissues issignificantly higher than that in adjacent tissues and correlated with tumor size,which may provide a reference for research of lung cancer.