| Schizophrenia is a type of severe mental disorder that has not yet been clarified.It is a young adult,especially in early adulthood.It is a chronic disease course,and it is difficult to heal and change symptoms.It is thought,cognition,emotion,behavior and There are many obstacles in social function and other aspects,and the external environment is inconsistent with the patient’s inner mental activities.When the patient is aware,most of the orientation is complete and the intelligence is still good.However,the disease is prone to recurrence or worsening,and the social function and intelligence are gradually declining,leading to mental disability.According to WTO estimates,the lifetime prevalence of schizophrenia in the full range is about 3.8‰-8.4‰.The lifetime prevalence of schizophrenia in China is 1%,the incidence rate is about 70/100,000,and more than half of the patients hospitalized in psychiatric hospitals are schizophrenia.At present,the treatment of schizophrenia is still based on drug treatment,supplemented by other non-drug treatments,atypical antipsychotic drugs,with little or no treatment of severe extrapyramidal symptoms and elevated levels of prolactin,clinically Get a wide range of applications.At the same time as the treatment of mental illness itself,the changes in blood sugar,blood lipids and sex hormones caused by atypical antipsychotics have attracted more and more people’s attention.The lesions caused by other medical treatments have begun to attract people’s attention.More and more people are beginning to pay attention to the side effects caused by antipsychotic treatment may affect bone metabolism.In human life,the skeletal system continues to destroy and absorb bone.Osteoporosis is characterized by decreased bone density,destruction of bone microstructure and bone fragility fracture,which is the main feature affecting the health and quality of life of most people.One of the main reasons.In addition to irreversible factors such as heredity and age,there are still many factors such as partial eclipse,less physical exercise,excessive smoking and drinking,and drug abuse,which can affect the change of bone density in daily life and affect the destruction and absorption of bone.At present,bone mineral density is a common indicator for predicting,diagnosing osteoporosis and predicting osteoporotic fractures,while bone turnover biochemical indicators such as osteocalcin and beta collagen-specific sequence levels are more sensitive indicators than bone density,and can be more effectively predicted.To diagnose osteoporosis and monitor the efficacy of medications.The aim of this study was to investigate the effects of second-generation atypical antipsychotics on changes in glycolipids and sex hormone levels in patients with schizophrenia and their possible levels of osteocalcin and beta-collagen.OBJECTIVE: The purpose of this study was to investigate the effects of the second-generation antipsychotic drugs risperidone and amisulpride on the levels of glycosphate and sex hormones in patients with schizophrenia and their specific levels of osteocalcin and beta-collagen.Possible related factors.Methods: A total of 93 patients with schizophrenia who were admitted to our hospital from April 20 to December 2018 in our hospital Jingzhou Mental Health Center were enrolled.Age 18-45 years old,gender is not limited.Among them,30 patients took amisulpride,33 patients took risperidone,and 30 patients with untreated schizophrenia were used as controls.Collect general demographic data(gender,height,age,weight,education level,place of residence,occupation,smoking and drinking status,activity status,history of falls,fracture history,total disease duration,etc.,and take antipsychotic patients in both groups)Time,type,dose,etc.of taking the drug.)Collect 5 ml of fasting venous blood in the morning(6:30-7:30),detect blood sugar(GLU),blood lipids including total cholesterol(CHOL),triglyceride(TG),LDL,HDL and sex hormone prolactin(PRL),estradiol(E2,female)(β-CROSSL)level.Statistical analysis was performed using SPSS 25.0 software.The general data and laboratory test results were compared between the three groups(the first untreated group,the amisulpride group,and the risperidone group)using variance analysis.The data were expressed as mean ± standard deviation(x ± s),p < 0.05 is statistically significant.The variances of GLU,TG,and β-CROSS are the same,and the P value under variance analysis can be directly used.The remaining indicators are not uniform and cannot be analyzed by variance.Therefore,the nonparametric test is used.Age,body weight,body mass index,total disease duration,drug dose,time of administration,and non-parametric tests were performed on CHOL,HDL,LDL,PRL,TESTO,BGP,and E2.The two categorical variables such as gender,smoking,drinking,partial eclipse,and activity intensity were selected by the chi-square test.Further,the parameters of the male and female groups in the amisulpride and risperidone groups were compared using the independent sample t-test p<0.05.The difference was statistically significant.Pearson correlation analysis was used to analyze the correlation between general data and laboratory results and osteocalcin(BGP)and serum β-collagen-specific sequence(β-CROSSL).Multivariate stepwise regression analysis was used to analyze the possible factors affecting biochemical markers of bone turnover.Results: 1.Comparison of general data and laboratory results(1)Comparison between the three groups: first-time unmedicated group,amisulpride group,risperidone group,age,body weight,body mass index(BMI),course of disease,HDL,PRL,CHOL,BGP,E2,TESTO The difference was statistically significant(p < 0.05)BGP(P-value 0.067)may vary,the sample size needs to be increased,and the difference in β-CROSS is not statistically significant.(2)Compared with the first-time untreated group,the amisulpride group showed an increase in age,weight,duration of disease,BMI,PRL,and CHOL,and decreased E2,HDL,and TESTO.The difference was statistically significant.(3)Compared with the first-time untreated group,the risperidone group had higher age,duration of disease,PRL,and decreased HDL,and the difference was statistically significant.(4)Compared with the risperidone group,the amisulpride group had elevated weight,BMI,CHOL and LDL,and the difference was statistically significant.(5)Further analysis of male and female groups in the amisulpride group showed: age,medication time,dose,GLU,PRL difference was statistically significant.(6)Further analysis of male and female groups in the risperidone group: PRL differences were statistically significant.2 correlation analysis:(1)Analysis of the correlation between general data and laboratory results of β-CROSSL in the amisulpride group and risperidone group and the first group of untreated group,the results showed: BMI,CHOL,E2,LDL is negatively correlated with β-CROSSL,and β-CROSSL is positively correlated with BGP(2)Analysis of the general data and laboratory results of schistosomiasis patients in the amisulpride group and the risperidone group and the first-time untreated group and the results showed that: BMI,CHOL,LDL,and BGP is negatively correlated and β-CROSSL is positively related to BGP.(3)Correlation between gender data and laboratory results of the amisulpride group and β-CROSSL showed that the time of medication was negatively correlated with β-CROSSL in male patients taking amisulpride.There was a negative correlation between BMI and P-CROSSL in female patients.The age,total duration,and dose of the patients were positively correlated with β-CROSSL.(4)Correlation between gender data and laboratory results in the amisulpride group showed that,in male patients taking amisulpride,body weight,BMI and medication time were negatively correlated with BGP,GLU,PRL,and BGP is positively correlated.weight,and BMI were negatively correlated with BGP among female patients.(5)Correlation between gender data and laboratory results in the risperidone group and β-CROSSL showed that body weight was negatively correlated with β-CROSSL in male patients taking risperidone.Female patients had a negative correlation between body weight,body mass indexof administration,and a dose of the drug,E2,and β-CROSSL.(6)Correlation between gender data and laboratory results of the risperidone group and BGP showed that BMI was negatively correlated with BGP in female patients taking risperidone.3 Multivariate stepwise regression analysis showed:(β-CROSSL)as the dependent variable,grouping,gender,body mass index,(CHOL),(TG),(LDL),(HDL),(GLU),(PRL)(BGP As an independent variable,multivariate stepwise linear regression shows that the degree of regression is OK,and the main influencing factors have a decisive effect on β-CROSSL.Conclusion:1.Amisulpride can affect the glucose and lipid metabolism and sex hormone levels in patients with schizophrenia.It is as follows: increase PRL,CHOL level,reduce,E2,HDL,TESTO,risperidone can affect glucose and lipid metabolism in patients with schizophrenia And the level of sex hormones,which showed elevated levels of PRL and reduced HDL,and amisulpride increased the levels of CHOL and LDL in patients compared with risperidone.CHOL,E2,LDL were negatively correlated with β-CROSSL,BMI,CHOL,LDL were negatively correlated with BGP,β-CROSS was positively correlated with BGP,and changes in blood lipids,prolactin and sex hormone levels were affected by BGP and β-CROSSL metabolism.2 Amisulpride caused an increase in BMI in women,which affected the metabolism of β-CROSSL in women.The resulting increase in body weight,BMI and PRL had an effect on male BGP metabolism.The increase in body weight and BMI had an effect on female BGP metabolism.3.Risperidone causes E2 reduction in patients to have an effect on β-CROSSL metabolism in women.Risperidone-induced weight,BMI,and PRL increase have an effect on female BGP metabolism. |
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