| Objective: 1.Analyze the relative power characteristics of each frequency band in different brain regions(prefrontal region,frontal region,parietal region,occipital region,temporal region)in patients with PSD,in order to provide theoretical support for the early diagnosis and early intervention of patients with post-stroke depression.2.Analyze the relationship between the severity of depression and NIHSS score,lesion site,lesion size,TOAST type and RP in patients with PSD.Analyze the relationship between the NIHSS score and RP.Methods: The study collected a total of 60 stroke patients hospitalized in our hospital from March 2018 to November 2018,and 28 patients in the outpatient health control group.HAMD score was performed on the enrolled patients.Patients with stroke were assessed by NIHSS score,TOAST type assessment,lesion size assessment,and lesion site analysis,and clinical data were collected.EEG was performed on the 7th day after illness,and the EEG in the artifact-free background phase was selected for 1 minute.The characteristics of the relative power of each frequency band in different brain regions in PSD group,PSND group and healthy control group and the characteristics of the relative power of each frequency band in different brain regions in patients with different severity of PSD were analyzed.Finally,SPSS21.0 software was used for statistical analysis of the data to obtain the final results.Results: 1.There were no significant differences in age,gender,history of hypertension,diabetes,smoking and drinking between the healthy control group,PSND group and PSD group(P > 0.05).There was no statistical difference in gender,history of hypertension,history of diabetes and history of smoking between groups of PSD patients with different degrees(P > 0.05),but there was statistical difference in age and history of drinking(P < 0.05).2.The NIHSS and HAMD scores of the healthy control group,the PSND group and the PSD group showed statistical differences(P < 0.05),and the scores of the PSD group were significantly higher than those of the other two groups.The NIHSS and HAMD scores compared among the groups with different severity of PSD indicated that the severity level of the group was significantly higher than that of the other groups,with statistical difference(P < 0.05).It can be concluded that the higher the degree of PSD,the higher the NIHSS score.3.There was no statistical difference in the relationship between PSD severity groups and lesion site(P > 0.05).The larger the infarct area,the more severe the PSD(P < 0.05).TOAST typing had no correlation with the severity of PSD(P > 0.05).4.In the prefrontal area,the relative power of β1 in the PSD group was lower than that in the healthy control group and the PSND group(P < 0.05).In the frontal area,the relative power of β2 in the PSD group was lower than that in the PSND group(P < 0.05).In the temporal region,the relative power of α1 was lower in the PSND group than in the control group(P < 0.05),and higher in the PSD group than in the PSND group(P < 0.05).The relative power of β1 was higher in the PSND group than in the control group(P < 0.05),and lower in the PSD group than in the PSND group(P < 0.05).The relative power of β2 in PSD group was lower than that in PSND group(P < 0.05).In the parietal region,the relative power of β1 and β2 was higher in the PSND group than in the control group(P < 0.05),and lower in the PSD group than in the PSND group(P < 0.05).In the occipital region,the relative power of β2 was higher in the PSND group than in the control group(P < 0.05),and lower in the PSD group than in the PSND group(P < 0.05).5.In the prefrontal area,the relative power of α1 was lower in the PSD group and higher in the PSND group than in the PSD group(P < 0.05).The relative power of α2 was lower in the severe depression group than in the positive depression group,and higher in the positive depression group than in the PSND group and the probable depression group(P < 0.05).The relative power of β1 in the PSD group was lower than that in the PSND group(P < 0.05).The relative power of the major depression group was higher than that of PSND group and positive depression group(P < 0.05).In the frontal area,the positive depression group had a higher relative power of α2 than the PSND and possibly depression groups(P < 0.05).The relative power of β2 in positive depression group and severe depression group was lower than that in PSND group and probable depression group(P < 0.05).The relative power of δ in the major depression group was higher than that of the PSND group,the probable depression group,and the positive depression group(P < 0.05).In the temporal region,the relative power of α1 was higher in the positive depression group and the severe depression group than in the PSND group(P < 0.05).The relative power of α2 in positive depression group was higher than that in PSND group and possibly depression group(P < 0.05).The relative power of β1 in the severe depression group was lower than that in the PSND group(P < 0.05).The relative power of β2 in the positive and severe depression groups was lower than that in the PSND group(P < 0.05).The relative power of δ in the major depression group was higher than that of the PSND group,the probable depression group,and the positive depression group(P < 0.05).In the parietal region,the relative power of α2 was higher in the positive depression group and the severe depression group than in the PSND group and the probable depression group(P < 0.05),lower in the β1 group than in the PSND group and the probable depression group(P < 0.05),and lower in the β2 group than in the PSND group(P < 0.05).The relative power of δ in the major depression group was higher than that of the PSND group,the probable depression group,and the positive depression group(P < 0.05).In the occipital region,the positive depression group had higher relative power of α2 than the PSND group and the probable depression group(P < 0.05).The relative power of β2 in the positive depression group and the severe depression group was lower than that in the PSND group(P < 0.05),and the relative power of β2 in the positive depression group was lower than that in the probable depression group(P < 0.05).The relative power of δ in the major depression group was higher than that of PSND group and positive depression group(P < 0.05).There was no statistical difference in the relative power of the other regions between the groups(P > 0.05).6.In frontal,temporal,and occipital regions,the relative power of β2 in patients with severe stroke was higher than that in patients with moderate stroke(P < 0.05).In the parietal region,the β2 relative power was higher in patients with severe stroke than in the mild and moderate stroke groups(P < 0.05).In the occipital region,the relative power of α2 was lower in patients with severe stroke than in patients with moderate stroke(P < 0.05).The β2 relative power was higher in patients with severe stroke than in patients with mild stroke(P < 0.05).The β2 relative power was lower in patients with moderate stroke than in patients with mild stroke(P < 0.05).There was no statistical difference in the rest of the relative power between the three groups(P > 0.05).7.The RP of θ in the prefrontal region was positively correlated with NIHSS score,while the relative power of other brain regions in different frequency bands was not correlated with NIHSS score.RP of β1 in prefrontal area,frontal area,parietal area,RP of β2 in frontal and temporal regions were negatively correlated with HAMD scores,RP of δ in prefrontal,frontal,temporal regions were positively correlated with HAMD scores.Conclusion: 1.Among stroke patients,Among stroke patients,depression was more severe in the age group younger than 60 than in the age group older than 60 or older.Stroke patients with a history of alcohol use were more likely to be depressed.2.The higher the NIHSS score,the higher the PSD severity.Patients with massive cerebral apoplexy are more likely to suffer from severe depression after stroke.3.The characteristics of RP in each frequency band are of early guiding significance for patients with post-stroke depression,and the RP of δ in each brain region(prefrontal region,frontal region,top region,occipital region,and temporal region)of patients with severe depression after stroke is higher than that of other groups with different degrees of depression.The RP of β2 was higher in patients with severe stroke than in patients with mild or moderate stroke.4.RP of β1 in prefrontal area,frontal area,parietal area,RP of β2 in frontal and temporal regions were negatively correlated with HAMD scores,RP of δ in prefrontal,frontal,temporal regions were positively correlated with HAMD scores.RP of θ in the prefrontal region was positively correlated with NIHSS score. |
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