| ObjectiveThrough investigation and analysis,this study explored whether the basic factors such as the age,education level,family income,and place of residence of pregnant mothers affect the vitamin A level in the third trimester of pregnancy;through investigation and analysis,explore the diet of pregnant women(vegetables,fruits,desserts,milk,barbecue)Whether animal liver,egg,puffed food,nuts,vitamin A supplements frequency and other factors affect the vitamin A level in the third trimester of pregnancy;by measuring the serum vitamin A concentration in late pregnancy and the vitamin A concentration in neonatal cord blood,understand The level of vitamin A concentration in the two,analyze the relationship between the two vitamin A concentrations,and further explore the effect of vitamin A deficiency in pregnant women on the level of vitamin A in neonates,in order to facilitate the early prevention and early prevention of vitamin A in the maternal and child public health center.Interventions provide strong scientific information and evidence for better development of maternal and child health care in the future,and better comprehensively maintain the health of pregnant women and the health and growth of newborns.MethodsThis study selected 300 pregnant women from the obstetrics department of the Affiliated Central Hospital of Shenyang Medical College from June 2017 to June 2018 in the Department of Obstetrics and Gynecology of Shenyang Medical College and delivered them in our hospital.All of them signed the informed consent form and adopted high performance liquid chromatography.(HPLC)to detect the concentration of vitamin A in the serum of peripheral blood of pregnant women in the third trimester.Among them,200 cases(66.67%)of newborns who met the criteria for full-term health and birth,and completed the vitamin A test of cord blood,and collected the basic information of 200 pregnant women through questionnaires and admission records,(age,education,family monthly income,place of residence,etc.)and diet(vegetables,fruits,desserts,milk,barbecue,animal liver,eggs,puffed food,nuts,vitamin A supplements).The content of the questionnaire was filled in by the special investigator to understand the level of vitamin A concentration in the third trimester of pregnancy,and the pregnant women in the third trimester of pregnancy were divided into two groups according to the vitamin A concentration of the pregnant mother,that is,the normal vitamin A group(0.3-0.7mg/L)(1mg/L=3.49p.mol/L)and the pregnant mother vitamin A deficiency group(<0.3mg/L),basic information for the two groups of indicators(age,education,family monthly income,Comparison of the place of residence and diet(vegetables,milk,fruits,desserts,barbecue,animal liver,eggs,puffed food,nuts,vitamin A supplements),analysis of the basic information of pregnant mothers and dietary factors The effects of advanced vitamin A levels.Furthermore,the correlation between the concentration of vitamin A in pregnant mothers and newborns was analyzed.The pregnant women in the third trimester of pregnancy were divided into two groups according to their serum vitamin A concentration,which was divided into normal VA group(0.3-0.7 mg)./L)(1mg/L=3.49μmol/L)and pregnant women VA deficiency group(<0.3mg/L),according to the vitamin A concentration of their newborn cord blood,each subdivided into the newborn VA normal group(0.3-0.7mg/L)and neonatal VA deficiency group(<0.3mg/L),analyze the data and draw conclusions.Results1.There were 300 pregnant women in the third trimester of pregnancy who completed the vitamin A test,accounting for about 15%of the total number of pregnant women in the obstetrics hospital.The total number of newborns who completed the vitamin A test and met the inclusion criteria was 200.A total of 200 pregnant mothers and 200 newborns who gave birth were included.2.The age of the pregnant mother,the pre-pregnancy BMI,and the median gestational age at the time of blood collection(5-95 percentile)were 30(19-45)years old,20.4(17.1-27.8)kg/M2,33(32-37)weeks.3.In this study,111(55.5%)of newborn boys and 89(44.5%)of girls,the median(5-95 percentile)of birth weight and gestational age were 3.4(2.7-4.0).)kg,38(37-41)weeks.4.In this study,a total of 200 pregnant women and newborns completed the vitamin A test in the third trimester of pregnancy.Among them,the median(5-95 percentile)of the vitamin A concentration in pregnant mothers was 0.29 mg l/L,and the newborn was 0.25 mg/L.114 cases(57.00%)of pregnant women had serum vitamin A deficiency,and 104(91.23%)of the corresponding neonates had different levels of vitamin A deficiency;86(43.00%)pregnant women had normal serum vitamin A and 26(30.23)%)The corresponding neonatal vitamin A deficiency varies.5.Pregnant women in the third trimester will be divided into two groups based on the concentration of vitamin A.That is to say,the pregnant mother vitamin A normal group(0.3-0.7mg/L)and the pregnant mother vitamin A deficiency group(<0.3mg/L),analysis of the basic information of the two groups(age,education level,family monthly income,residence(ground),using the χ2 test,the difference in the educational level of the two groups of different vitamin A levels(χ2=11.83,P=0.003)was statistically significant(P<0.05);the two groups of different vitamin A levels of the pregnant mother There was no significant difference in age(χ2=4.05,P=0.132),family monthly income(χ2=2.40,P=0.301),and residence(χ2=0.21 8,P=0.641)(P>0.05).6.Pregnant women in the third trimester will be divided into two groups based on the concentration of vitamin A.In other words,the pregnant mother vitamin A normal group(0.3-0.7mg/L)and the pregnant mother vitamin A deficiency group(<0.3mg/L),the diet of the two groups of people(vegetables,fruits,desserts,milk,barbecue,Animal liver,eggs,puffed food,nuts,vitamin A supplements frequency of supplements)using χ2 test analysis,found two groups of different vitamin A levels of vegetables(χ 2=7.40,P = 0.025),fruits(χ 2 = 9.96,P =0.007),milk(χ2=10.81,P=0.004),animal liver(χ2=12.15,P=0.002),eggs(χ2=15.54,P=0.000)and vitamin A supplement supplement frequency(χ2= 7.21,P=0.027)The difference in intake was statistically significant(P<0.05);two groups of different vitamin A levels were desserts(χ2=2.1 7,P=0.33 7)and barbecues(χ2=3.79,P=0.150).There was no significant difference in the intake of puffed foods(χ2=1.74,P=0.420)and nuts(χ2=7.21,P=0.053)(P>0.05).7.Multi-factor analysis,using two-class logistic regression to obtain vegetables,milk,fruits,animal liver,eggs,education level and vitamin A supplement supplement frequency(≥ 1 times/day)can play a protective role,that is,to maintain pregnant women It is beneficial that the VA content is within the normal range(0.3-0.7 mg/L).8.Pearson analyzed the relationship between 200 pairs of vitamin A levels in the serum of the mother in the third trimester of pregnancy and the cord blood of the newborn.The results were correlated(r=0.908,P<0.05)and were very strong.Relevance.The pregnant women in the third trimester were divided into the normal vitamin group(0.3-0.7 mg/L)(1 mg/L=3.49μmol/L)and the pregnant women with VA deficiency group(<0.3 mg)./L),according to the vitamin A concentration of their newborn cord blood,each subdivided into the newborn VA normal group(0.3-0.7mg/L)and neonatal VA deficiency group(<0.3mg/L),using χ 2 Analysis,the difference was statistically significant(χ2=80.166,P<0.05).Conclusions1.This study found that the number of pregnant women and neonates with vitamin A deficiency in the third trimester of pregnancy in our hospital accounted for 57%and 65%of the total.2.The median(5-95 percentile)of pregnant women’s vitamin A concentration was 0.29 mg/L,and the newborn was 0.25 mg/L.The average vitamin A content was lower.3.The vitamin A content of pregnant women in the third trimester was related to the maternal education level(P<0.05),and was not related to the maternal age,family monthly income and place of residence(P>0.05).It is recommended that pregnant mothers have rich knowledge about vitamin A.Popularize and understand its importance to itself and the newborn.4.Vitamin A levels in pregnant women in the third trimester are related to dietary factors,which are related to the frequency of supplementation of vegetables,fruits,milk,animal liver,eggs and vitamin A supplements(P<0.05);they are not related to desserts,barbecues,puffed foods and nuts.(P>0.05),it is recommended to eat more foods that are conducive to increasing vitamin A content during pregnancy,thereby increasing serum VA levels and preventing disease.5.The frequency of education,vegetables,milk,fruits,animal liver,eggs and vitamin A supplements(≥1 times/day)can protect the level of vitamin A in late pregnancy.It is suggested that the pregnant mother can realize the disadvantages of the imbalance of vitamin A intake,which is beneficial to balance the diet during pregnancy.This has played an essential role in improving the vitamin A level during pregnancy.6.Serum vitamin A levels in pregnant women were positively correlated with vitamin A levels in neonatal cord blood(r=0.908,P<0.05),and had a strong correlation,the difference was statistically significant(χ2=80.166,P<0.05),lack of VA during pregnancy is easy to lead to a lack of VA in newborns.7.Vitamin A levels should be tested in a timely manner during pregnancy.Improve vitamin A levels in the body,thereby reducing the prevalence and mortality of vitamin A deficiency in pregnant women and newborns,and better maintaining maternal health and the health and growth of newborns. |
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