Study Changes Of Bone Mineral Density And Bone Metabolism Markers In Middle-aged Male Patients With Coronary Heart Disease

Objective:To investigate the changes of bone mineral density and bone metabolism in middle-aged male patients with coronary heart disease.To study the relationship between the severity of coronary artery disease and bone mineral density in middle-aged men with coronary heart disease.To provide a basis for routine screening of bone density in patients with coronary heart disease and attention to screening of the risk of coronary heart disease in patients with low bone densityMethods: 122 middle-aged male patients with coronary heart disease and110 middle-aged male patients without coronary heart disease were enrolled in this study,divided into 2 groups:coronary heart disease group and non-coronary heart disease group.Collect from patients with age,weight,height,blood pressure,history of hypertension,history of diabetes,history of smoking,blood sugar,serum creatinine,uric acid,homocysteine,thyroid function,25-hydroxyvitamin D3,alkaline phosphatase,osteocalcin and other biochemicalindicators,all subjects using dual energy X-ray absorption meter determination of hip and lumbar spine bone mineral density.The Gensini score was used to assess the severity of coronary artery stenosis.Results:(1)The proportion of serum homocysteine,low-density lipoprotein and hypertension in CHD group was higher than that in non-chd group,and the difference was statistically significant(P < 0.05).There was no significant difference in age,BMI,systolic blood pressure,diastolic blood pressure,blood glucose,serum creatinine,blood lipid,uric acid,thyroid function,smoking history and diabetes in the CHD group and the non-chd group(P >0.05).(2)Analysis of related risk factors of coronary heart disease;Logistic regression analysis of related risk factors after the valuation of dependent variables and various suspected influencing factors showed that low bone mass,high serum homocysteine and 25 hydroxyvitamin D3 deficiency were risk factors of coronary heart disease.(3)Among CHD patients,BMD was divided into the normal bone mass group and the low bone mass group(due to the small number of patients with osteoporosis,the patients with osteoporosis and reduced bone mass were combined into the low bone mass group).The blood calcium in the low bone mass group was higher than that in the normal bone mass group,and the difference was statistically significant(P < 0.05).BMI of the group with low bone mass was lower than that of the group with normal bone mass,and the difference was statistically significant(P < 0.05).Age,smoking history,systolic pressure,diastolic blood pressure or hypertension,diabetes,blood glucose,serum creatinine,uric acid,blood lipids,blood homocysteine,thyroid function,blood phosphorus,parathyroid hormone,alkaline phosphatase and osteocalcin,25 hydroxy vitamin D3 in bone mass normal group and there was no statistically significant difference between the low bone mass group(P > 0.05).(4)AmongCHD patients,the Gensini score in the low bone mass group was higher than that in the normal bone mass group,and the difference was statistically significant(P <0.05).The results of Person correlation analysis showed that low BMD was positively correlated with the degree of coronary artery stenosis.Conclusion:(1)Lumbar and hip BMD of middle-aged male patients with coronary heart disease was lower than that of non-coronary heart disease patients;(2)Low bone mineral density,high homocysteinemia and25-hydroxyvitamin D deficiency may be risk factors for coronary heart disease in middle-aged men;(3)Low BMD was correlated with degree of coronary artery stenosis in middle-aged male patients with coronary heart disease;(4)Routine bone mineral density and vitamin D examination should be conducted for middle-aged male patients with coronary heart disease to timely detect bone loss and vitamin D deficiency and timely treat them.In addition to the active control of traditional risk factors for coronary heart disease,the improvement of low bone mass and vitamin D deficiency in middle-aged men can be used as measures to prevent and treat coronary heart disease.