| Objective: To investigate the related factors affecting gastric juice volume in the first 24 hours after radical resection of distal gastric cancer,and to detect the number of interstitial cells of Cajal in gastric tissue samples of patients after radical resection of distal gastric cancer.The relationship between gastric juice volume and gastric juice volume after operation was analyzed.Methods:From May 2017 to March 2018,24 patients with distal gastric cancer underwent D2 radical gastrectomy in the Department of Gastrointestinal Glands,First Affiliated Hospital of Guangxi Medical University were collected.The general data of the patients were collected,including gender,age,BMI,associated diseases(hypertension,diabetes),preoperative anemia and preoperative hypoproteinemia.Surgical data,including surgical methods,operation time,intraoperative bleeding volume.Postoperative data included pathological stage and 24-hour gastric juice volume.The full-thickness tissues of proximal incision margin,gastric body incision margin and distal incision margin were taken from 24 patients with gastric cancer after operation.The expression of interstitial cells of Cajal in different parts was observed under lightmicroscope by immunohistochemical staining with c-kit antibody.The possible influencing factors of 24-hour gastric juice volume after operation were analyzed by univariate analysis with general data,operative data,postoperative data and the number of interstitial cells of Cajal in different sites(P < 0.05).Linear analysis was made between the number of interstitial cells of Cajal in different parts of gastric tissue and the volume of gastric juice 24 hours after operation(P < 0.05).Results:(1)The single factor analysis showed that 24 hours gastric juice in the hypertensive group before gastric cancer operation was more than that in the non-hypertensive group(61.00 ± 10.77 VS 49.95 ± 8.12,P = 0.044),the difference was statistically significant;24 hours gastric juice in the diabetic group before gastric cancer operation was more than that in the non-diabetic group before gastric cancer operation(62.40 ± 10.73 VS 49.58 ±7.54,P =0.019),and the difference was statistically significant.The number of interstitial cells of Cajal in proximal gastric tissue(<1/200HPF)group was more than that in proximal gastric tissue(>1/200HPF)group(56.38 ±8.89 VS 44.00 ±4.34,P=0.001)24 hours after operation,and the difference was statistically significant.There was no significant difference in other data groups(P > 0.05).There was no significant difference in the number of interstitial cells of Cajal between different sites in general data(gender,age,BMI,hypertension,diabetes),preoperative anemia and preoperative hypoproteinemia)(P > 0.05).(2)Linear regression analysis showed that there was a linear relationship between the number of Cajal interstitial cells in proximal gastric tissue and the volume of gastric juice 24 hours after operation(P < 0.05).Conclusion:1.Preoperative hypertension in patients with distal gastric cancer isassociated with increased gastric juice volume 24 hours after surgery.2.Preoperative diabetes mellitus in patients with distal gastric cancer is associated with increased gastric juice volume 24 hours after surgery.3.The number of Cajal interstitial cells in proximal gastric tissue is correlated with the volume of gastric juice 24 hours after operation.There is a linear relationship between the number of Cajal interstitial cells in proximal gastric tissue and the volume of gastric juice 24 hours after operation.Especially,the number of Cajal interstitial cells in proximal gastric tissue(<1/200 HPF)is correlated with the volume of gastric juice 24 hours after operation. |
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