The Study Of Correlation Between The TCM Syndrome Typingros Crohn’s Disease(CD)and Clinical Efficacyion Fecal Microbiota Transplantation

Objective: By surveying and analyzing the clinical character of Crohn’s Disease,the study aimed to analyze the TCM syndrome typing of Crohn’s Disease,and the correlation between common TCM syndrome typing and clinical efficacy of FMT(Fecal Microbiota Transplantation).Through the study we can understand CD deeply,and get more clinical guidelines.Methods:The subjects of the study were patients of the second affiliated hospital of Nanjing medical university gastroenterology inpatient department which were diagnosed as Crohn’s Disease(CD)within June to November 2018.Based on diagnostic criteria,inclusion and exclusion criteria,90 patients aged 14 to 65 were included in the study.Based on understanding of patients,we helped them accomplish question-naires,including basic information,medical history,TCM syndrome typing.After questionnaires were accomplished,we processed data,set up a database.In addition,27 patients who were diagnosed as active CD and performed FMT,matched inclusion and exclusion criteria,were included in part ii research.By questionnaires and follow-up observation after FMT one week,one month,we analyzed the correlation between common TCM syndrome typing and clinical efficacy of FMT.The Microsoft Office 2010 Excel and SPSS20.0 were used to analyze data,the count data was described in percentage,measurement data was described in mean±standard deviation.chi-square test was applied for count data comparison.Student’s t test or analysis of variance was applied for measurement data comparison.Results:1.A total of 90 patients were included in the study of part one.1.1 The general information:57 male and 33 female were included in this part,sex ratio was 1.7.The average age was 35.6year old,most of they between 14 to 65.34.44% patients had a balanced diet,48.89% patients liked spicy food,13.33% liked fat and rich food,so about 65.56% of them had unbalanced diet.34 patients considered diet as inducement of CD,29 patients selected emotion(anxiety,anger),16 patients selected cold climate.About half of them didn’t take exercise one hour weekly,four fifths of them didn’t take exercise one and a half hour weekly.1.2 Characteristic of CD: diseased region of CD patients were ileocolon(58.89%),next end of the ileum(18.89%),colon(15.56%),upper gastrointestinal tract(6.67%).Most patients occurred abdominal pain and diarrhea,fatigue,anemia,loss of weight,few complications and outside intestine manifestation.1.3 TCM syndrome types:90 cases had been analyzed,for basic types,depressed liver and deficient spleen(34.44%),deficiency-cold in spleen and stomach(18.89%),qi stagnancy and blood stasis(16.67%),spleen deficiency dampness obstruction (15.56%),large intestine damp-heat syndrome(14.44%).Depress-ed liver and deficient spleen,large intestine damp-heat syndrome were common in active stage,deficiency-cold in spleen and stomach was common in catabasis.Deficiency and excess,deficiency(37.78%),intermingled deficiency and excess(36.67%),Cold and heat,cold(34.44%).2.A total of 27 patients were included in the study of part two.2.1 The HBI score in two group after FMT one week,one month were better than before FMT(P<0.05),the difference had significance.The HBI score in hot group after FMT one week was better than one month(P<0.05),but the clod group was not.2.2 Before FMT,the HBI score in two group hadn’t difference.After FMT one week,the HBI score in hot group was better than the clod group,the difference had significance.After FMT one month,two group hadn’t difference.Conclusion:1.Most CD patients were male,most patients lack of exercise and balanced diet.Diet,emotion,clod climate were considered as inducement.Diseased region of CD patients were ileocolon,next end of the ileum,colon,upper gastrointestinal tract.Most patients occurred abdominal pain and diarrhea,fatigue,anemia loss of weight.2.For basic types,mainly depressed liver and deficient spleen,and then deficiency-cold in spleen and stomach,qi-stagnation and blood stasis,spleen deficiency dampness obstruction,large intestine damp-heat syndrome.Most patients showed cold and heat mixed complex lesions,deficiency syndrome.3.FMT had remedial effect to CD,and could reduce HBI score.4.FMT which was similar to “jinzhi ” had the effect of clearing away heat and detoxification.