Research Of Correlation Between Serum Calcium And Magnesium Levels And Rupture Of Intracranial Saccular Aneurysm

Objective: To investigate the correlation between serum calcium and magnesium levels and rupture of intracranial saccular aneurysm.Method: 374 patients with intracranial cystic aneurysm were selected from August 2012 to June 2018 in the First Affiliated Hospital of Guangxi Medical University.According to whether the aneurysm were ruptured,128 cases were divided into ruptured group and 246 cases into unruptured group.Relevant clinical data,laboratory indicators and imaging data were collected at admission.The effects of serum calcium and magnesium levels on rupture of intracranial saccular aneurysm were analyzed by univariate analysis and multivariate logistic regression,with statistical significance of P<0.05.Result: Univariate analysis showed that the levels of serum calcium,magnesium and platelet in ruptured group were lower than those in non-ruptured group,and the INR value in ruptured group was higher than that in non-ruptured group(P < 0.05).Multivariate logistic regression analysis showed that serum calcium(OR: 0.513,95% CI: 0.310-0.847)and tumor size(OR: 0.695,95% CI: 0.540-0.895)were associated with rupture of intracranial saccular aneurysm(P < 0.05).However,sex,age,smoking history,drinking history,hypertension,serum magnesium and tumor location were not found to be associated with the rupture of cystic aneurysm(P > 0.05).Conclusion: The results showed that serum magnesium level were not significantly correlated with rupture of intracranial saccular aneurysm.Serum calcium levels are associated with rupture of intracranial saccular aneurysm,but further prospective studies with large samples are needed.