Prognostic Significance Of Peripheral Absolute Lymphocyte Count,Absolute Monocyte Count And Lymphocyte/monocyte Ratio In Peripheral T-cell Lymphoma

Objective:This study aims to investigate the prognostic significance of peripheral absolute lymphocyte count(ALC),absolute monocyte count(AMC)and their ratio(lymphocyte/monocyte ratio,LMR)in newly diagnosed peripheral T-cell lymphoma(PTCL).Methods:The clinical data of 51 newly diagnosed peripheral T-cell lymphoma patients from January 2008 to July 2017 in Department of Hematology and Oncology,Binzhou Medical University Hospital were collected.We retrospectively analyzed ALC,AMC,LMR and other datas of all the patients.Receiver Operating Characteristic Curve(ROC)was used to obtain the optimal cut-off values of continuous variables such as ALC,AMC and LMR,respectively,and patients were grouped.OS was analyzed using Kaplan-Meier curves,which were compared using log-rank tests.Multivariate prognostic analyses of OS were performed using the Cox proportional hazards regression model.Results:A total of 51 newly diagnosed PTCL patients were enrolled in this study,including 36 males and 15 females.The optimal cut-off values of ALC,AMC and LMR were 1.17×109/L,0.41 ×109/L and 3.94.There was significant difference in ECOG score between low AMC group(AMC<0.41 ×109/L)and high AMC group(AMC>0.41 × 109/L)(P=0.018).There were significant differences in ECOG score and B symptoms between low LMR group(LMR≤3.94)and high LMR group(LMR>3.94)(P<0.05).There was no significant correlation between the level of ALC and other clinical features.The OS rate was 39.2%.Univariate survival analysis showed that the 2-year OS rate was lower in low ALC group(ALC<1.17×109/L)than in high ALC group(ALC>1.17 ×109/L),accounting for 26.4%and 61.1%.The 2-year OS rate was also significantly lower in the low LMR group(26.1%)than in the high LMR group(90%).The differences were statistically significant(P=0.022 and P=0.001),meaning that both low ALC and low LMR may indicate poor prognosis.There was no significant correlation between AMC and 2-year overall survival.Multivariate survival analysis revealed that only ALC,clinical stage and ECOG score were independent prognostic factors of 2-year overall survival in PTCL patients.Conclusions:Low ALC and low LMR suggest that patients with peripheral T-cell lymphoma have a poor prognosis,and ALC is an independent prognostic factor for OS.There was no significant correlation between AMC and 2-year overall survival.