Effect Of Anticoagulant Therapy On PICC Related Thrombosis In Breast Cancer

Objective:Detection of Plasma TF,TFPI,TF/TFPI,PLT,APTT,PT,FIB Levels in Patients with PICC After Breast Cancer Surgery,looking for the timing of anticoagulant drugs;evaluating anticoagulant therapy by monitoring venous blood flow velocity and thrombosis The role of PICC-related thrombosis in breast cancer.Method:To collect 120 cases of female breast cancer after PICC in a tertiary level A hospital,one of the patients collected in the ward was the experimental group,and the other patient was the control group.After the PICC was uniformly implanted,the experimental group was abdomen.Subcutaneous heparin calcium 4100U was administered subcutaneously once daily for 3 days,no anticoagulant drugs were used in the control group.Two groups of laboratory indicators,blood flow velocity,and thrombosis were observed.Result:There was no significant difference in the laboratory parameters before and after the PICC implantation in the two groups(P>0.05);The levels of TF,TFPI,TF/TFPI,and PLT and FIB were lower in the experimental group than in the three days after the PICC was implanted.Before,the difference between the two groups was statistically significant(P<0.05);There was no significant difference in TF,TFPI,TF/TFPI,PLT and FIB between the two groups at 2 weeks after PICC implantation(P>0.05);In the first month after PICC implantation,the TF,TFPI,TF/TFPI,PLT and FIB were significantly higher than those before implantation,and the difference was statistically significant(P<0.05).There was no significant change in blood flow velocity between the two groups at different time points.There was no significant difference between the two groups(P>0.05).The incidence of thrombosis in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).There was a statistically significant difference in the time of thrombosis between the two groups(P<0.05).Conclusion:PICC thrombus anticoagulant therapy was selected one to two weeks after catheterization;Prophylactic injection of nadroparin calcium after PICC placement can reduce the incidence of thrombosis in postoperative breast cancer patients.