Extraintestinal Manifestations Of Ulcerative Colitis In Xinjiang

Objective:To analyze the clinical characteristic and risk factors of extraintestina l manifestation in ulcerative colitis(UC)and to improve the knowledge and treatm ent of UC with extraintestinal manifestation.Methods:From January 2013 to September 2018,at the Department of Gastroenterol ogy,People’s Hospital of Xinjiang Uygur Autonomous Region,304 hospitalized patie nts diagnosed as UC were collected.The demographic characteristics,clinical phenoty pes and extraintestinal manifestations were analyzed.Results:(1)Among 304 UC patients,45.1%(137/304)had extraintestinal manifestatio n,including fatty liver disease(17.1%,52/304),gallbladder stone(11.5%,35/304),typeⅠperipheral arthritis(7.6%,23/304),oral ulcer(4.6%,14/304),erythema nodosum(40.%,12/304),typeⅡperipheral arthritis(3.0%,9/304),Cholestasis(2.0%,6/304),irirei tis(1.6%,5/304),sacroiliitis(1.6%,5/304),conjunctivitis(1.6%,5/304),ankylosing sp ondylitis(1.6%,5/260),Psoriasis(1.6%,5/260),pyoderma gangrenosum(1.3%,4/304),primary sclerosing cholangitis(1.3%,4/304),uveitis(0.7%,2/304).(2)age,history of i ntestinal surgery and body mass index(BMI)could affect the occurrence of extrain testinal manifestation in patients with UC(χ~2=14.364、8.932、18.448,all P<0.05).T he incidence of extraintestinal manifestation in UC patients in the active phase was higher than that of UC patients in the inactive phase(58%,117/202,vs 19.6%,20/102),and he difference was statistically significant(χ~2=4.424,P<0.05).(3)Multivar iate analysis showed that BMI≥24kg/m~2,with a history of intestinal surgery and acti ve disease were risk factors for UC patients with Extraintestinal manifestation(P<0.05).Conclusion:UC is complicated with a variety of extraintestinal manifestations.The most commonly involved organs are liver and gallbladder,joint and oral cavity.BMI≥24kg/m~2,with a history of intestinal surgery and active disease are importan t risk factors for UC patients with EIM.