Efficacy Of Purging Stomach And Invigorating Spleen Acupuncture Therapy On Type 2 Diabetes Mellitus And Its Effect On GLP-1

Objective:1.To observe the clinical effect of Purging Stomach and Invigorating Spleen Acupuncture Therapy on patients with type 2 diabetes mellitus.2.To further observe the effect on GLP-1 and to explore the mechanism of it in the treatment of type 2 diabetes mellitus.Methods:63 patients were randomly divided into acupuncture plus Western medicine group(32 patients)and Western medicine group(31 patients)by random number table.Patients in both groups maintained the original drug treatment and diet control.Patients in the acupuncture plus Western medicine group were treated with acupuncture on the basis of the original drug treatment and lifestyle intervention.The main acupoints of Purging Stomach and Invigorating Spleen Acupuncture Therapy are Zhongwan,Zusanli,Neiting,Pishu,Sanyinjiao and Taibai.The method of reducing by lifting,thrusting,twirling,and rotating the needles in Zhongwan,Zusanli and Neiting.Pishu,Sanyinjiao and Taibai were given the method of reinforcing by lifting,thrusting,twirling,and rotating the needles.The needles of Pishu were withdrawled after stimulating it,others were kept of 30 minutes.The treatment was given three times a week and a course of treatment last for one month.The observation period was three months.Before and after treatment,the TCM symptom score,fasting blood glucose(FBG),2h postprandial blood glucose(2hPG),glycosylated hemoglobin(HBA1c),TG,TC,LDL-C,HDL-C,C-peptide(0 points)and glucagon-like peptide 1(GLP-1)of patients were recorded respectively,and the efficacy was compared and evaluatedResults:1.Comparison of TCM symptom scores of patients between two groups:Before and after intervention,the difference in scores between the two groups was statistically significant(P<0.05);Compared with the Western medicine group,the TCM symptom score of the acupuncture plus Western medicine group was lower than that of the Western medicine group,and the difference was statistically significant(P<0.05).2.Fasting blood glucose,2h postprandial blood glucose,and glycosylated hemoglobin:FPG,2hPG,and HbAlc in the two groups were both significantly reduced after the intervention,with statistically significant differences(P<0.05).Compared with the Western medicine group,FPG,2hPG and HbAlc in acupuncture plus Western medicine group were significantly reduced(P<0.05).3.TG,TC,LDL-C,HDL-C:Both groups showed statistically significant difference in TC,LDL-C,HDL-C after the intervention.And the change of TC,LDL-C,HDL-C in the acupuncture plus Western medicine group after intervention was significantly greater than that in the Western medicine group(P<0.05).There was no significant decrease in TG between the two groups before and after intervention,and the difference was not statistically significant(P>0.05).4.C-peptide and GLP-1:Compared with that before intervention,GLP-1 and fasting C-peptide in both groups were higher,and the difference was statistically significant(P<0.05).The levels of GLP-1 and fasting C-peptide in the acupuncture plus Western medicine group were higher than those in the Western medicine group,and the difference was statistically significant(P<0.05).Conclusion:The main pathogenesis of type 2 diabetes mellitus in TCM is strong stomach and weak spleen.Acupuncture based on the therapy of purging stomach and invigorating spleen can effectively control the blood sugar and blood lipid levels,elevate the fasting C-peptide and GLP-1 of the patients,and to decrease the scores of TCM symptom so as to improve quality of patients’ lives.Its mechanism maybe related to improve islet beta cells secrete insulin,improve the level of GLP-1 in the body,regulate glucolipid metabolism.