BIRC5,ABCC3,CDC20,ASPM Novel Networks And Analysis And Verification Of Human Lung Adenocarcinoma From Big Data

BIRC5,ABCC3,CDC20 and ASPM molecular and knowledge networks were originally reconstructed,put forward and verified the novel hypothesis from GEO Dataset GSE7670 by gene selection algorithm significance analysis of microarrays(SAM),gene reconstruction network infer(GRNInfer),the database for annotation visualization and integrated discovery(DAVID).Based on positive net number results of BIRC5,ABCC3,CDC20 and ASPM activation minus inhibition in lung adenocarcinoma compared with human normal adjacent tissues,BIRC5 network illustrates lung adenocarcinoma developmental process value as 7,microtubule cytoskeleton 6,nucleus 1;ABCC3 network shows transporter activity and membrane fraction as 3;CDC20 network reveals protein catabolic process as 1,regulation of cell cycle 2;ASPM network demostrates intracellular membrane-bound organelle as 5,mitosis 3 in lung adenocarcinoma.Based on negative net number results of BIRC5,ABCC3,CDC20 and ASPM activation minus inhibition in lung adenocarcinoma compared with human normal adjacent tissues,BIRC5 network illustrates cytoplasm value as-5,alternative splicing-6;ABCC3 network shows glycoprotein-9;CDC20 network reveals protein binding as-1,sequence variant-3 in lung adenocarcinoma.We put forward that BIRC5 network enhances nucleus microtubule cytoskeleton based lung adenocarcinoma developmental process whereas inhibites cytoplasm alternative splicing;ABCC3 network increases membrane transporter activity whereas represses extracellular glycoprotein;CDC20 network induces protein catabolic process-related cell cycle regulation whereas inhibites protein binding-based sequence variant;APSM network enhances intracellular membrane-bound organelle-related mitosis.Our hypothesis are mutually,positively and negatively verified by BIRC5,ABCC3,CDC20 and ASPM activation and inhibition knowledge networks.They are very useful to identify potential targets for prognosis and therapy of human lung adenocarcinoma.