Investigation And Analysis Of Patients’Traditional Chinese Medicine Constitution Type With Vascular Dementia In Guangxi Region And Study On The Intervention Of The Sequential Treatment Of Triple Energizer

Objective: To investigate the TCM constitution type of vascular dementia patients in Guangxi area and analyze its pathogenesis.To compare the clinical efficacy of western medicine combined with sequential treatment of tri-jiao and western medicine in the treatment of vascular dementia in Guangxi area and reveal the mechanism of its curative effect.Methods:(1)In accordance with the inclusion and exclusion criteria,120 patients with vascular dementia in Guangxi area were collected from March2017 to February 2018 in the Department of Cerebropathy,the First Affiliated Hospital of Guangxi University of Chinese Medicine,the Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,and Nanning Hospital of Chinese medicine,which were investigated with questionnaire of TCM constitution type.(2)In accordance with inclusion and exclusion criteria,76 cases of kidney deficiency and phlegm obstruction type’s vascular dementia in Guangxi area were collected from March 2018 to February 2019 in the Department of Cerebropathy,the first affiliated Hospital of Guangxi University of Chinese Medicine,which were randomly divided into two groups: treatment group(n=38)and control group(n=38),and the control group were treated with routine western medicine(Donaipaiqi hydrochloride tablet),and the treatment group were treated with routine western medicine combined with the sequential treatment of tri-jiao.The course of treatment in both groups was for 4 weeks.MMSE scores,serum Ach and NO levels,safety index were compared between the two groups before and after treatment.Results:(1)The investigation results of TCM constitution type were as follows:(1)The TCM constitution types of vascular dementia patients in Guangxi area was mainly phlegm and dampness,accounting for 21.66%of the total.(2)The age grades of the patients with vascular dementia in the Guangxi area was 65-75 years old,accounting for 51.66% of the total number.(3)There was negative correlation between the degree of education and the incidence of vascular dementia in Guangxi area.(2)The results of clinical research were as follows:(1)Compared with the two groups before and after treatment,the MMSE scale score was significantly higher than that before treatment(P<0.05),and the treatment group was superior to the control group in improving the cognitive function of the patients.(2)Compared with the two groups before and after treatment,the serum Ach level was significantly higher and the NO value was significantly lower in the treatment group than in the control group’s(P<0.05),and the treatment group is superior to the control group.Serious adverse reactions were not observed after applying the therapeutic regimen to the study,and there was no damage to the liver and kidney function before and after treatment in the two groups.Conclusion: The main results are as follows:(1)The TCM constitution type of vascular dementia patients in Guangxi area is mainly phlegm and dampness,and the incidence is mainly in the elderly,and the lower education level,the higher incidence of the disease.(2)The clinical curative effect of routine western medicine therapy combined with the sequential treatment of tri-jiao is better than that of routine western medicine therapy for kidney deficiency and phlegm obstruction type’s vascular dementia in Guangxi area,and the mechanism may be related to the increase of serum Ach level and decrease of serum NO level,and there is no toxic and side effect,whose safety is well.