Study On The Correlation Between MCP-1 And Systemic Vasculitis

Objective: Monocyte chemotactic protein 1(MCP-1)plays a significant role in inflammation pathways by affecting monocyte/macrophage migration,the number of monocytes and T lymphocytes,and osmosis.Inflammation is closely linked to various types of systematic vasculitis.Here we characterized serum MCP-1 levels in systemic vasculitis patients.Methods: This cross-sectional study included serum samples collected from 43 patients with systemic vasculitis and 43 healthy controls(HCs).Serum MCP-1 levels in the samples were measured using commercially available enzyme-linked immunosorbent assay(ELISA)kits.Results: Serum MCP-1 levels were significantly higher in patients with systemic vasculitis relative to HCs and essential hypertension(parentheses indicate quartile values)[134.65(73.74,262.75)pg/mL,59.1(37.41,90.18)pg/mL,68.43(65.42,104.84)pg/mL,P< 0.001].Furthermore,systemic vasculitis patients having renal involvement had significantly higher MCP-1 levels relative to patients without renal involvement [196.16(104.41,310.35)pg/mL versus 73.74(41.24,145.95)pg/mL,P= 0.001] and HCs [196.16(104.41,310.35)pg/mL versus 59.10(37.41,90.18)pg/mL,P< 0.001].Serum MCP-1 levels in systemic vasculitis patients were positively correlated with serum creatinine levels(r = 0.387,P< 0.010)and with 24-h proteinuria(r = 0.404,P< 0.014).Receiver operating characteristic(ROC)analysis showed that the cutoff value for MCP-1 to distinguish systemic vasculitis from HCs was 72.73 pg/ml,and the area under the ROC curve was 0.772.The sensitivity and specificity were 76.7% and 72.1%,respectively.Conclusion: Serum MCP-1 levels were significantly higher in patients with systemic vasculitis than in HCs and essential hypertension,especially in patients with renal involvement.Thus,serum MCP-1 has the potential to be a biomarker for systemic vasculitis with renal involvement.