Association Of The PD-L1 Expression With Clinicopathologic Characteristics And Prognostic Value In Patients With Bladder Urothelial Carcinoma

Objective:To evaluate the expression of programmed death-ligand 1(PD-L1)in Chinese poeple with bladder urothelial carcinoma(UC)and investigate the association of PD-L1 expression with clinicopathological features and clinical outcomes.Methods:Tumor specimens which meet the conditions were collected from patients with UC who received radical nephroureterectomy or cystoscope biopsy in our center from 2009 to 2016.Tumor samples were evaluated for PD-L1 membrane expression on tumor cells(TC)or tumor-associated immune cells(IC)by immunohistochemistry(IHC).Association between PD-L1 with clinicopathologic characteristics and survival analysis were evaluated with SPSS software.Results:PD-L1 is widely expressed in bladder urothelial carcinoma,approximately 32.7%of urothelial carcinoma had positive PD-L1 expression,abaot 27.8%of tumor cell and 9.9%of immune cell demonstrated positive PD-L1 expression.The expression of PD-L1 in tumor cell were significantly associated with poor clinicopathologic characteristics.However,It was observed between PD-L1 expression on immune cell with better survival and prognosis.In addition,PD-L1 positivity on tumor cell was independent risk factors for disease-free survival(DFS).PD-L1 positivity on immune cell was independent good factors for overall survival(OS).Conclusions:The expression of PD-L1 in tumor cell and immune cell was significantly associated with clinicopathologic characteristics and survival outcomes.