Analysis Of Clinical Characteristics Of 66 Cases In Kawasaki Disease Complicated With Joint Dysfunction

Objective: To analyze the clinical characteristics and laboratory indicators of Kawasaki disease complicated with joint movement disorder,aiming to improve the early diagnosis rate of children.Methods: We retrospectively collected and analyzed the clinical data of 66 children with Kawasaki disease complicated with joint dysfunction(experimental group)and 75 children with non-joint dysfunction Kawasaki disease(control group)randomly selected from Children’s Hospital of Chongqing Medical University from May 1999 to September 2017.Results: 1.In the experimental group,the affected joint was distributed in the head and neck,the hip and the lower extremity,the incidence was 81.82%and 12.12%and 6.06%,respectively.The incidence of the imaging changes was 83.33% and 100% and 50%,respectively.2.The incidence of neck lymphadenopathy,oral mucosal congestion,bulbar conjunctiva congestion,toe swelling or desquamation and rash in the experimental group was significantly lower than that in the control group.3.The number of leukocytes,platelets,neutrophils,C-reactive protein,and the erythrocyte sedimentation rate were increased in the two groups.While the number of neutrophil,C-reactive protein and the erythrocyte sedimentation rate in the experimental group were significantly higher than those in the control group,and the platelets were significantly lower.Three days after body temperature stabilization,the values of some inflammatory indexes included leukocytes,neutrophils,C-reactive protein,erythrocyte sedimentation rate(ESR)in the two groups were decreased,while the values of platelets rised.Moreover,the number of neutrophils in the experimental group were significantly higher than those in the control group.4.30 cases(45.46%)of coronary artery dilatation in the experimental group were significantly higher than that of the control group in 21 cases(28.00%).Conclusion: The joint dyskinesia in children with Kawasaki disease were mainly distributed in the head and neck.The initial clinical manifestations of Kawasaki disease complicated with joint movement disorder were atypical,and the inflammatory indexes were significantly increased.Patients with joint dyskinesia are more prone to coronary artery dilatation.It is necessary to fully recognize the clinical characteristics of Kawasaki disease to facilitate the diagnosis and treatment as early as possible in combination with course of disease and laboratory examination.